Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
The Human K-Complex Represents an Isolated Cortical Down-State
Sydney S. Cash,Eric Halgren,Nima Dehghani,Andrea O. Rossetti,Thomas Thesen,Chunmao Wang,Orrin Devinsky,Ruben Kuzniecky,Werner Doyle,Joseph R. Madsen,Edward B. Bromfield,Loránd Erőss,Péter Halász,George Karmos,George Karmos,Richard Csercsa,Lucia Wittner,István Ulbert,István Ulbert +18 more
TL;DR: It is shown that KCs are generated in widespread cortical areas by outward dendritic currents in the middle and upper cortical layers, accompanied by decreased broadband EEG power and decreased neuronal firing, which demonstrate a steep decline in network activity.
Journal ArticleDOI
Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants.
Tohei Yokogawa,Wilfredo Marin,Juliette Faraco,Guillaume Pézeron,Guillaume Pézeron,Lior Appelbaum,Jian-Jian Zhang,Frédéric M. Rosa,Frédéric M. Rosa,Philippe Mourrain,Emmanuel Mignot,Emmanuel Mignot +11 more
TL;DR: This study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates.
Journal ArticleDOI
Homer1a is a core brain molecular correlate of sleep loss
Stéphanie Maret,Stéphane Dorsaz,Laure Gurcel,Sylvain Pradervand,Brice Petit,Corinne Pfister,Otto Hagenbüchle,Bruce F. O'Hara,Paul Franken,Mehdi Tafti +9 more
TL;DR: The consistent activation of Homer1a suggests a role for sleep in intracellular calcium homeostasis for protecting and recovering from the neuronal activation imposed by wakefulness.
Journal ArticleDOI
Cytokines and sleep
TL;DR: Because cytokines regulate/modulate sleep-wake behavior in the absence of immune challenge, and cytokine concentrations and profiles are altered during infection, it is likely that cytokines mediate infection-induced alterations in sleep.
Journal ArticleDOI
Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila.
TL;DR: Using Western blots and confocal microscopy in Drosophila, it is found that protein levels of key components of central synapses were high after waking and low after sleep, and sleep may be involved in maintaining synaptic homeostasis altered by waking activities.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.