Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
The increase in longitudinally measured sleepiness across adolescence is related to the maturational decline in low-frequency EEG power.
TL;DR: The data support the hypothesis that, independent of sleep schedule changes, increasing adolescent daytime sleepiness is related to brain maturational changes indexed by declining EEG power.
Journal ArticleDOI
Sleep Patterns and Homeostatic Mechanisms in Adolescent Mice
TL;DR: It is hypothesized that, in young adolescent mice, a ceiling effect and not the immaturity of the cellular mechanisms underlying sleep homeostasis may prevent the SWA rebound when wake is extended beyond its physiological duration.
Journal ArticleDOI
The neurobiological basis of sleep: Insights from Drosophila
TL;DR: A comprehensive summary of the neurobiology of Drosophila sleep is provided and the broader insights and implications of how sleep is regulated across species and why it is necessary for the brain are explored.
Journal ArticleDOI
Low-frequency stimulation induces stable transitions in stereotypical activity in cortical networks.
Ildiko Vajda,Ildiko Vajda,Jaap van Pelt,P.S. Wolters,Michela Chiappalone,Sergio Martinoia,Eus J.W. Van Someren,Eus J.W. Van Someren,Arjen van Ooyen +8 more
TL;DR: It is shown for the first time that low-frequency electrical stimulation can induce long-lasting alterations in spontaneous activity of cortical neuronal networks and whether the observed transformations in network activity could represent a switch in attractor state.
Journal ArticleDOI
The micro-architecture of the cerebral cortex: functional neuroimaging models and metabolism.
TL;DR: The background at the microscopic scale is summarized, which is suggested to constitute the foundations for upcoming representations at the mesoscopic level, and basic principles and mechanisms underlying cellular metabolism in the cerebral cortex are summarized.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.