Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.
Grasielle C. Kincheski,Isabela S. Valentim,Julia R. Clarke,Danielle Cozachenco,Morgana T. Castelo-Branco,Angela M. Ramos-Lobo,Vivian M. Rumjanek,Jose Donato,Fernanda G. De Felice,Fernanda G. De Felice,Sergio T. Ferreira +10 more
TL;DR: Results substantiate the notion of a dual relationship between sleep and AD, whereby Aβ Os disrupt sleep/wake patterns and chronic sleep restriction increases brain vulnerability to AβOs, and point to a key role of brain inflammation in increased susceptibility to A βOs in sleep-restricted mice.
Journal ArticleDOI
Slow wave sleep during a daytime nap is necessary for protection from subsequent interference and long-term retention.
TL;DR: It is the conclusion that SWS, obtained only by those in the 60-min nap group, served to actively facilitate the consolidation of learned bimodal paired-associates, supported by theories such as the Standard Theory of Consolidation as well as the Synaptic Homeostasis Hypothesis.
Book ChapterDOI
Sleep's effects on cognition and learning in adolescence.
TL;DR: Ass associations of reduced sleep with poorer school performance beg the question of how prelearning and posttraining sleep affect the learning process, and strong evidence indicates that adequate sleep enhances memory consolidation and resistance to interference.
Journal ArticleDOI
No Associations between Interindividual Differences in Sleep Parameters and Episodic Memory Consolidation.
Sandra Ackermann,Sandra Ackermann,Francina Hartmann,Andreas Papassotiropoulos,Dominique J.-F. de Quervain,Björn Rasch,Björn Rasch +6 more
TL;DR: The results indicate that individual differences in sleep are much less predictive for Pictorial memory processes than previously assumed and suggest that previous studies using small sample sizes might have overestimated the association strength between sleep stage duration and pictorial memory performance.
Journal ArticleDOI
The history and current state of antidepressant clinical trial design: a call to action for proof-of-concept studies.
Alan J. Gelenberg,Michael E. Thase,Roger E. Meyer,Frederick K. Goodwin,Martin M. Katz,Helena C. Kraemer,William Z. Potter,Richard C. Shelton,Maurizio Fava,Arif Khan,Madhukar H. Trivedi,Philip T. Ninan,J. John Mann,Susan Bergeson,Jean Endicott,James H. Kocsis,Andrew C. Leon,Husseini K. Manji,Jerrold F. Rosenbaum +18 more
TL;DR: Better early-stage POC studies are needed and should be able to amplify the signal strength of drug efficacy and enhance the quality of information in clinical trials of new medications with novel pharmacologic profiles.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.