Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
More filters
Journal ArticleDOI
Sleep-dependent consolidation of statistical learning
TL;DR: It is demonstrated that abstraction of statistical patterns benefits from sleep, and the first clear support for the role of slow-wave sleep in this consolidation is provided.
Journal ArticleDOI
Sleep Deprivation Increases A1 Adenosine Receptor Binding in the Human Brain: A Positron Emission Tomography Study
David Elmenhorst,Philipp T. Meyer,Oliver H. Winz,Andreas Matusch,Johannes Ermert,Heinz H. Coenen,Radhika Basheer,Helmut L. Haas,Karl Zilles,Andreas Bauer +9 more
TL;DR: This is the first molecular imaging study that provides in vivo evidence for an A1 AR upregulation in cortical and subcortical brain regions after prolonged wakefulness, indicating that A1AR expression is contributing to the homeostatic sleep regulation.
Journal ArticleDOI
Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review
Gabriel Villafuerte,Adán Miguel-Puga,Eric Murillo Rodríguez,Sergio Machado,Elias Manjarrez,Oscar Arias-Carrión +5 more
TL;DR: A meta-analysis of basic studies in mice and rats to drive the hypothesis that sleep is a dynamic-resting state with antioxidative properties and the complex relationship between sleep duration and oxidative stress is discussed.
Journal ArticleDOI
Common mechanisms of human perceptual and motor learning
TL;DR: Evidence is examined supporting the notion that perceptual and motor learning in humans exhibit analogous properties, including similarities in temporal dynamics and the interactions between primary cortical and higher-order brain areas, that may point to the existence of a common general mechanism for learning in human.
Journal ArticleDOI
Sleep leads to changes in the emotional memory trace: Evidence from fmri
TL;DR: Evidence is provided for a shift in the neural structures used to retrieve emotional memories after a night of sleep compared to a day of wakefulness that led to a shift from engagement of a diffuse memory retrieval network to a more refined network of regions.
References
More filters
Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.