Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Such stuff as dreams are made on? Elaborative encoding, the ancient art of memory, and the hippocampus
TL;DR: This article argues that rapid eye movement (REM) dreaming is elaborative encoding for episodic memories, and that the stuff of dreams is thestuff of memory if this hypothesis is correct.
Journal ArticleDOI
Unihemispheric sleep and asymmetrical sleep: behavioral, neurophysiological, and functional perspectives
TL;DR: In dolphins, eared seals, and manatees, unihemispheric sleep allows them to have the benefits of sleep, breathing, thermoregulation, and vigilance, but in domestic chicks, antipredation vigilance is the main function of uni Hemispheric Sleep, and it is suggested that they involve the interaction of structures of the hypothalamus, basal forebrain, and brain stem.
Journal ArticleDOI
Impact of sleepiness and sleep deficiency on public health--utility of biomarkers.
TL;DR: It is important to recognize that sleepiness and sleep deficiency are not synonymous, and it is necessary to select patients suitable for sleep restriction based on prior history of sleep problems.
Journal ArticleDOI
Structural brain correlates of human sleep oscillations.
TL;DR: In this article, the morphology of the human brain offers one explanatory factor of inter-individual variability in sleep physiology, showing that gray matter volume in interoceptive and exteroceptive cortices correlated with the expression of slower NREM sleep spindle frequencies, supporting their role in sleep protection against conscious perception.
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Slow-Wave Activity Enhancement to Improve Cognition
TL;DR: The robustness and practicality ofSWA-enhancement techniques are evaluated, approaches for determining a causal role of SWA on cognition are discussed, and questions to clarify the mechanisms of SWa-dependent cognitive improvements are presented.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.