Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Synaptic plasticity in sleep: learning, homeostasis, and disease
Gordon X. Wang,Brian P. Grone,Damien Colas,Lior Appelbaum,Philippe Mourrain,Philippe Mourrain +5 more
TL;DR: It is suggested that sleep creates a heightened state of plasticity, which may be essential for this optimization of synaptic circuits and how sleep deficits seen in diseases such as Alzheimer's disease and autism spectrum disorders could also play a direct role in the progression of those disorders.
Journal ArticleDOI
The neuroinflammatory response of postoperative cognitive decline
TL;DR: Non-resolution of inflammation is explored as an underlying cause of developing exaggerated and persistent POCD in elderly surgical patients and interventions can be developed to promote resolution of neuroinflammation.
Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation ROELINA HAGEWOUD, R OBBERT H AVEKES, A RIANNA N OVATI, JAN N. K EIJSER, E DDY A.VAN D ER Z EE and PETER M EERLO
TL;DR: In this article, the authors investigated whether sleep deprivation for 6 or 12 hours during the normal resting phase prior to learning a novel arm recognition task significantly impaired hippocampus-dependent working memory in mice.
Journal ArticleDOI
Effects of sleep manipulation on cognitive functioning of adolescents: A systematic review
TL;DR: This systematic review examined the effects of experimental sleep manipulation on adolescent cognitive functioning and found that total or partial sleep restriction, sleep extension, and sleep improvement were successful.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.