Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium.
Jennifer L. DeWolfe,Beth A. Malow,John R. Huguenard,Robert Stickgold,Blaise F. D. Bourgeois,Gregory L. Holmes +5 more
TL;DR: The dynamic symbiotic relationship between sleep and epilepsy was explored at the 2011 Merritt-Putnam Symposium, and knowledge of the behavioral and EEG features of nonepileptic sleep disorders and nocturnal epilepsy are required to appropriately manage the patient.
Journal ArticleDOI
Reactivation-induced motor skill learning.
TL;DR: In this paper, the authors showed that the quality of memory reactivation, reflected by its continuity, regulates the magnitude of learning gains, and that high continuity reactivations resulted in higher learning gains.
Book ChapterDOI
Neuroimaging Studies of Sleep and Memory in Humans
TL;DR: How sleep contributes to the long-term consolidation of recently acquired memories in light of contemporary neural models for memory consolidation during sleep is discussed.
Journal ArticleDOI
Current Approaches and Challenges to Development of an Individualized Sleep and Performance Prediction Model~!2009-03-22~!2010-05-11~!2010-07-15~!
Journal ArticleDOI
Adenosine Shifts Plasticity Regimes between Associative and Homeostatic by Modulating Heterosynaptic Changes.
TL;DR: It is shown that at neocortical synapses in slices from rat visual cortex, adenosine modulates the weight dependence of heterosynaptic plasticity: blockade ofadenosine A1 receptors abolished weight dependence, while increased adenosines level strengthened it.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.