Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Effects of state and trait anxiety on sleep structure: A polysomnographic study in 1083 subjects.
András Horváth,András Horváth,Xavier Montana,Jean Pol Lanquart,Philippe Hubain,Anna Szűcs,Paul Linkowski,Gwenolé Loas +7 more
TL;DR: It was found that both state and trait anxiety affected non-rapid eye movement sleep parameters, predominantly associated to state anxiety while rapid eye movement parameters related to trait anxiety.
Journal ArticleDOI
Sleep-wake dynamics under extended light and extended dark conditions in adult zebrafish.
Benjamín Sigurgeirsson,Haraldur Þorsteinsson,Sigrún Sigmundsdóttir,Ramona Lieder,Hildur S. Sveinsdóttir,Olafur E. Sigurjonsson,Olafur E. Sigurjonsson,Bjarni V. Halldorsson,Karl A E Karlsson,Karl A E Karlsson +9 more
TL;DR: The results indicate that sleep duration is most effectively altered by varying exposure to ambient light, and zebrafish may exhibit weaker sleep homeostasis and sleep pressure than do mammals; and sleep deprivation does not significantly alter their stress responses.
Journal ArticleDOI
Reactivation and Consolidation of Memory During Sleep
Björn Rasch,Jan Born +1 more
TL;DR: It is argued that declarative memory consolidation during sleep is based on covert reactivations of newly encoded memory traces in the hippocampus, which is critical for the redistribution and integration of these memories into the network of pre-existing long-term memories.
Book ChapterDOI
Genetic Dissection of Sleep Homeostasis
Géraldine M. Mang,Paul Franken +1 more
TL;DR: The definition of sleep homeostasis is given and the molecular genetics techniques that are used to examine it are described, which provide a conceptual discussion on the problem of assessing aSleep homeostatic phenotype in various animal models and highlight some of the studies with a focus on clock genes and adenosine signaling molecules.
Iconographies supplémentaires de l'article : Impact on the brain of the inflammatory response to surgery
Sarah Saxena,Mervyn Maze +1 more
TL;DR: Consideration is provided how to identify the high-risk surgical patient and both pharmacological (including biological compounds) and non-pharmacological strategies to customize care.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.