Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Circadian Rhythms and Sleep in Drosophila melanogaster
Christine Dubowy,Amita Sehgal +1 more
TL;DR: Flies remain a valuable tool for both discovery of novel molecules and deep mechanistic understanding of sleep and circadian rhythms, and are beginning to understand how the identified molecules and neurons interact with each other, and with the environment, to regulate sleep.
Journal ArticleDOI
REM Sleep Reorganizes Hippocampal Excitability
Andres Grosmark,Kenji Mizuseki,Kenji Mizuseki,Eva Pastalkova,Kamran Diba,György Buzsáki,György Buzsáki +6 more
TL;DR: It is found that the overall firing rates of hippocampal CA1 neurons decreased across sleep concurrent with an increase in the recruitment of neuronal spiking to brief "ripple" episodes, resulting in a net increase in neural synchrony.
Journal ArticleDOI
Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study.
TL;DR: In this paper, cellular insulin sensitivity was reduced in adipocytes from subcutaneous fat from impaired sleep, and the molecular mechanisms by which impaired sleep increases insulin resistance are not fully understood.
Journal ArticleDOI
Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex
Kenji Mizuseki,György Buzsáki +1 more
TL;DR: Large-scale recordings from multiple layers of the entorhinal-hippocampal loop found that the firing rates of principal neurons showed a lognormal-like distribution in all brain states, implying that a preconfigured, highly active minority dominates information transmission in cortical networks.
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The influence of learning on sleep slow oscillations and associated spindles and ripples in humans and rats
TL;DR: This work examined whether slow oscillations also group learning‐induced increases in spindle and ripple activity, thereby providing time‐frames of facilitated hippocampus‐to‐neocortical information transfer underlying the conversion of temporary into long‐term memories.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.