Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
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Neural ensemble reactivation in rapid eye movement and slow-wave sleep coordinate with muscle activity to promote rapid motor skill learning
TL;DR: It is shown that reactivation occurs in both REM and SWS and that coordination of REM andSWS activation on the same day is associated with rapid learning of a motor skill, and that coordinated reactivation in both sleep states on theSame day, although at different times, is beneficial for skill learning.
Journal ArticleDOI
The relationship between prior night's sleep and measures of infant imitation
TL;DR: High sleep quality in the preceding night was positively associated with next day's memory encoding in 6-month-old infants, and significant correlations between nighttime sleep quality variables (sleep efficiency, sleep fragmentation) and immediate imitation in 6month-olds, but not in 12- month-olds.
Journal ArticleDOI
Toward noninvasive brain stimulation 2.0 in Alzheimer’s disease
TL;DR: In this article , the authors review and discuss experimental noninvasive brain stimulation (NiBS) applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleeprelated memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection.
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Brain white matter damage and its association with neuronal synchrony during sleep.
Erlan Sanchez,Héjar El-Khatib,Caroline Arbour,Christophe Bedetti,Hélène Blais,Karine Marcotte,Andrée-Ann Baril,Maxime Descoteaux,Danielle Gilbert,Julie Carrier,Nadia Gosselin +10 more
TL;DR: The results showed that the relationship between white matter and the brain's ability to synchronize during sleep is neither linear nor simple, and challenges the current line of hypotheses that white matter microstructure deterioration reduces cerebral synchrony during sleep.
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High-density electroencephalography as an innovative tool to explore sleep physiology and sleep related disorders.
TL;DR: The present review aims to offer a complete overview regarding the use of high density EEG over the last decade in sleep research and sleep medicine, including its possible future perspective.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
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Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.