Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Brain rhythm attractor breakdown in Alzheimer's disease: Functional and pathologic implications
TL;DR: This approach explains behavioral‐cognitive changes in AD across the sleep‐wake cycle and supports a causal association between early brainstem tau pathology and subsequent cortical amyloid β accumulation, which could explain deficient memory consolidation through dysregulation of synaptic plasticity.
Journal ArticleDOI
Sleep cyclic alternating pattern and cognition in children: a review.
TL;DR: It can be hypothesized that the analysis of CAP might be helpful in characterizing sleep microstructure patterns of different phenotypes of intellectual disability and a series of studies has been carried out that are reviewed, to achieve a unitary view of the role of CAP.
Journal ArticleDOI
Waking experience modulates sleep need in mice
L Milinski,Simon P. Fisher,Nanyi Cui,L E McKillop,C Blanco-Duque,Gauri Ang,T Yamagata,David M. Bannerman,Vladyslav V. Vyazovskiy +8 more
TL;DR: In this paper, the effects of repetitive behaviors such as wheel running or performing a simple touchscreen task, with wakefulness dominated by novel object exploration, on sleep timing and EEG slow-wave activity (SWA) during subsequent NREM sleep were investigated.
Journal ArticleDOI
Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice.
Kazuyoshi Kitaoka,Mika Shimizu,Noriyuki Shimizu,Sachiko Chikahisa,Madoka Nakagomi,Koichi Shudo,Kazuo Yoshizaki,Hiroyoshi Sei +7 more
TL;DR: The results suggest that the 4-week antagonism of RARs induces the attenuation of delta power, which may be elicited indirectly by the decrease of wakefulness followed by the hypo-expression of dopamine receptors especially D1DR.
Journal ArticleDOI
Reinforcing rhythms in the sleeping brain with a computerized metronome.
TL;DR: It is demonstrated that appropriately timed sounds delivered during sleep can invigorate electrophysiological oscillations conducive to memory stabilization, which is important in memory consolidation.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.