Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Functional structure of spontaneous sleep slow oscillation activity in humans
Danilo Menicucci,Andrea Piarulli,Ursula Debarnot,Paola D'Ascanio,Paola D'Ascanio,Alberto Landi,Alberto Landi,Angelo Gemignani,Angelo Gemignani +8 more
TL;DR: How SSO features are modulated by sleep stage, site of origin and detection location of the waves is unveiled, indicating that, as in animal models, onsets of silent states are more synchronized than those of neural firing.
Journal ArticleDOI
Sleep memory processing: the sequential hypothesis.
TL;DR: The sequential hypothesis (SH) memories acquired during wakefulness are processed during sleep in two serial steps respectively occurring during slow wave sleep (SWS) and rapid eye movement (REM) sleep which integrates them with preexisting memories.
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Astroglial regulation of sleep homeostasis
TL;DR: An emerging view that glial astrocytes may play an essential role in sleep homeostasis is discussed, suggesting that sleep drive may arise independently among neurons throughout the brain in a use-dependent fashion.
Journal ArticleDOI
Degeneracy in hippocampal physiology and plasticity
TL;DR: This review systematically catalogs lines of evidence, spanning multiple scales of analysis that point to the expression of degeneracy in hippocampal physiology and plasticity, and postulates that biological complexity, involving interactions among the numerous parameters spanning different scales ofAnalysis, could establish disparate routes towards accomplishing these conjoint goals.
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Poor sleep affects daytime functioning in typically developing and autistic children not complaining of sleep problems: A questionnaire-based and polysomnographic study
Andréane Lambert,Sophie Tessier,Annie-Claude Rochette,Peter Scherzer,Laurent Mottron,Roger Godbout +5 more
TL;DR: In this paper, the authors examined the relationship between sleep and behavior in prototypical autism spectrum (AS) children and non-autistic children not complaining of sleep problems, and found that sleep latency was longer in AS than in non autistic children.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.