Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Sleep in adolescence: physiology, cognition and mental health
TL;DR: It is suggested that brain activity during sleep may provide a unique window onto adolescent cortical maturation and compliment waking measures in adolescence, and how sleep actively supports waking cognitive functioning in adolescence is reviewed.
Journal ArticleDOI
Human Cortical Excitability Increases with Time Awake
Reto Huber,Hanna Mäki,Mario Rosanova,Silvia Casarotto,Paola Canali,Adenauer G. Casali,Giulio Tononi,Marcello Massimini +7 more
TL;DR: Noninvasive electrophysiological evidence that wakefulness is associated with a steady increase in the excitability of human cortical circuits that is rebalanced during sleep is provided.
Journal ArticleDOI
Sleep Oscillations in the Thalamocortical System Induce Long-Term Neuronal Plasticity
TL;DR: The results suggest that long-term potentiation occurs during slow-wave sleep, supporting its contribution to memory.
Journal ArticleDOI
Metabolic, endocrine, and immune consequences of sleep deprivation.
Laila AlDabal,Ahmed S. BaHammam +1 more
TL;DR: A molecular basis for the link between both entities and the underlying pathophysiology that results in insulin resistance and diabetes mellitus is explored, specifically examining the relationship between sleep duration and the immune and endocrine systems.
Journal ArticleDOI
Sleep and waking modulate spine turnover in the adolescent mouse cortex
TL;DR: This paper found that waking results in a net increase in cortical spines, whereas sleep is associated with net spine loss, and that synaptic strength is modulated by behavioral state, and asked whether synaptic remodeling may be affected by sleep and waking states.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.