Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
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Book
Rhythms of the brain
TL;DR: The brain's default state: self-organized oscillations in rest and sleep, and perturbation of the default patterns by experience.
Journal ArticleDOI
The memory function of sleep
Susanne Diekelmann,Jan Born +1 more
TL;DR: Sleep has been identified as a state that optimizes the consolidation of newly acquired information in memory, depending on the specific conditions of learning and the timing of sleep, through specific patterns of neuromodulatory activity and electric field potential oscillations.
Journal ArticleDOI
About sleep's role in memory
Bjoern Rasch,Jan Born,Jan Born +2 more
TL;DR: This review aims to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings.
Journal ArticleDOI
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
TL;DR: A plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention, and implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.
Journal ArticleDOI
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
TL;DR: Greater appreciation of the convergence of mechanisms between stress, depression, and neuroplasticity is likely to lead to the identification of novel targets for more efficacious treatments.
References
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Journal ArticleDOI
Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
TL;DR: Analyses of the (nonadditive) interaction of the circadian and sleep-dependent components of sleep propensity and sleep structure revealed that the phase relation between the sleep-wake cycle and the circadian pacemaker during entrainment promotes the consolidation of sleep and wakefulness and facilitates the transitions between these vigilance states.
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Practice with Sleep Makes Perfect: Sleep-Dependent Motor Skill Learning
TL;DR: Evidence is provided that a night of sleep results in a 20% increase in motor speed without loss of accuracy, while an equivalent period of time during wake provides no significant benefit.
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Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence? ☆
Irwin Feinberg,Irwin Feinberg +1 more
TL;DR: Evidence indicates that a profound reorganization of human brain function takes place during adolescence: the amount of deep sleep and the rate of brain metabolism fall sharply; the latency of certain event-related potentials declines; the capacity to recover function after brain injury diminishes; and adult problem-solving "power" appears.
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Long-term dendritic spine stability in the adult cortex
TL;DR: It is shown that filopodia-like dendritic protrusions, extending and retracting over hours, are abundant in young animals but virtually absent from the adult, providing a potential structural basis for long-term information storage.
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Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity
TL;DR: A novel form of cooperativity operating even when postsynaptic firing is evoked by current injection is demonstrated, and a complex dependence of LTP and LTD on rate and timing is revealed, providing a quantitative framework for predicting the impact of in vivo firing patterns on synaptic strength.