Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Molecular and Anatomical Signatures of Sleep Deprivation in the Mouse Brain
Carol L. Thompson,Jonathan P. Wisor,Changkyu Lee,Sayan Dev Pathak,Dmitry Gerashchenko,Kimberly A. Smith,Shanna R. Fischer,Chihchau L. Kuan,Susan M. Sunkin,Lydia Ng,Christopher Lau,Michael Hawrylycz,Allan R. Jones,Thomas S. Kilduff,Edward S. Lein +14 more
TL;DR: SD was found to both induce and suppress IEG expression in subregions of neocortex, striatum, and other brain regions, finding that robust molecular changes were largely restricted to the forebrain.
Journal ArticleDOI
Broadband local field potentials correlate with spontaneous fluctuations in functional magnetic resonance imaging signals in the rat somatosensory cortex under isoflurane anesthesia.
Wen-Ju Pan,Garth John Thompson,Matthew Magnuson,Waqas Majeed,Dieter Jaeger,Shella D. Keilholz +5 more
TL;DR: Findings suggest that resting-state fMRI signals might be a reflection of broadband LFP power modulation, at least in isoflurane-anesthetized rats.
Journal ArticleDOI
Sleep and synaptic renormalization: a computational study
TL;DR: A large-scale model of the corticothalamic system equipped with a spike-timing dependent learning rule is used to demonstrate a net increase in synaptic strength in the waking mode associated with an increase in neuronal firing rates and synchrony and an exponential, self-limiting renormalization of synaptic strength during sleep.
Journal Article
Sleep In A Dish: Key Electrophysiological, Molecular, And Metabolic Signatures Of Sleep And Wakefulness Revealed In Primary Cortical Cultures
V. Hinard,Cyril Mikhail,Sylvain Pradervand,Thomas Curie,R. Houtkooper,Johan Auwerx,Paul Franken,Mehdi Tafti +7 more
TL;DR: The EPFL-CONF-185256 Web of Science Record was created on 2013-03-28, modified on 2017-05-12 as discussed by the authors, and it was used for the 2013 Web-of-Science Record.
Book ChapterDOI
Sleep and recovery
TL;DR: This chapter summarizes the knowledge on sleep and restitution and results in restored alertness, memory capacity, and mood.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.