Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
Quantitative Proteomics of Sleep-Deprived Mouse Brains Reveals Global Changes in Mitochondrial Proteins.
TL;DR: This work used advanced quantitative proteomics technology to survey the global changes in brain protein abundance and observed significant enrichment for mitochondrial proteins among the differentially expressed proteins, suggesting connections between sleep loss, mitochondrial stress, and neurodegeneration.
Journal ArticleDOI
Human Heart Rhythms Synchronize While Co-sleeping.
Heenam Yoon,Sang Ho Choi,Sang Kyong Kim,Hyun Bin Kwon,Seong Min Oh,Jae-Won Choi,Yu Jin Lee,Do Un Jeong,Kwang Suk Park +8 more
TL;DR: Investigation of the heart rhythms of co-sleeping individuals found evidence that in co-sleepers, not only do independent heart rhythms appear in the same relative phase for prolonged periods, but also that their occurrence has a bidirectional causal relationship.
Journal ArticleDOI
Impact of sleep duration on executive function and brain structure
TL;DR: In this article , the authors examined sleep and cognitive data from the UK Biobank (N = 479,420) in middle-to-late life healthy individuals (age 38-73 years) and the relationship with brain structure in a sub-group (n = 37,553).
Journal ArticleDOI
The Impact of Sound on Electroencephalographic Waves during Sleep in Patients Suffering from Tinnitus
TL;DR: It is demonstrated that sound stimulation during sleep in tinnitus patients influences brain activity and open an avenue for investigating the mechanism underlying tinnitis and its treatment.
Journal ArticleDOI
Association Between Phase Coupling of Respiratory Sinus Arrhythmia and Slow Wave Brain Activity During Sleep.
Kyuichi Niizeki,Tadashi Saitoh +1 more
TL;DR: Analyzing how phase coupling of RSA is altered during sleep suggests that phase coupling analysis of RSA appears to be a marker for predicting SWS intervals, thereby complementing other noninvasive tools and diagnostic efforts.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.