Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
Citations
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Journal ArticleDOI
A dynamical role for acetylcholine in synaptic renormalization.
Christian G. Fink,Christian G. Fink,Geoffrey G. Murphy,Geoffrey G. Murphy,Michal Zochowski,Victoria Booth +5 more
TL;DR: It is shown that cholinergically-induced changes in network firing patterns alter overall network synaptic potentiation when synaptic strengths evolve through spike-timing dependent plasticity mechanisms, and this phenomenon is robust across variation of many different network parameters.
Journal ArticleDOI
Memory consolidation during sleep and adult hippocampal neurogenesis
Iyo Koyanagi,Katherine G. Akers,Pablo Vergara,Sakthivel Srinivasan,Takeshi Sakurai,Masanori Sakaguchi +5 more
TL;DR: There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, some new advances that were left untouched in the recent review are described.
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Cerebrolysin prevents sleep deprivation induced memory impairment and oxidative stress.
TL;DR: Results showed a protective effect for CBL administration against sleep-deprivation induced memory impairment, which could be related to CBL induced prevention of oxidative stress in the hippocampus.
Journal ArticleDOI
Induction of slow oscillations by rhythmic acoustic stimulation
TL;DR: In this article, the authors examined whether slow oscillations can be effectively induced by rhythmic acoustic stimulation and found that 0.8-Hz stimulation significantly delayed sleep onset and entrained endogenous slow oscillation activity.
Journal ArticleDOI
Sleep and hippocampus: Do we search for the right things?
TL;DR: This review attempts to reconcile some of the seemingly antagonistic theories of sleep function in a succinct and unbiased manner and develop an eclectic view of its role in learning and memory.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
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The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.