Journal ArticleDOI
Sleep function and synaptic homeostasis.
Giulio Tononi,Chiara Cirelli +1 more
TLDR
This paper reviews a novel hypothesis about the functions of slow wave sleep-the synaptic homeostasis hypothesis, which accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders.About:
This article is published in Sleep Medicine Reviews.The article was published on 2006-02-01. It has received 1864 citations till now. The article focuses on the topics: Synaptic scaling & Sleep and memory.read more
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Journal ArticleDOI
The Role of Memory Reactivation during Wakefulness and Sleep in Determining Which Memories Endure
TL;DR: It is proposed that memory consolidation depends on the covert reactivation of previously learned material both during sleep and wakefulness, and that covert reactivating is a major factor determining the selectivity of memory consolidation in these circumstances.
Journal ArticleDOI
Differential effects of non-REM and REM sleep on memory consolidation?
TL;DR: Several recent studies have related consolidation of procedural memories to SWS (or non-REM sleep)-dependent consolidation processes, and proposed future research questions to advance the understanding of the role of different sleep stages for memory consolidation.
Journal ArticleDOI
Separating the Contribution of Glucocorticoids and Wakefulness to the Molecular and Electrophysiological Correlates of Sleep Homeostasis
Valérie Mongrain,Susana A. Hernandez,Sylvain Pradervand,Stéphane Dorsaz,Thomas Curie,Grace Hagiwara,Phung Gip,H. Craig Heller,Paul Franken,Paul Franken +9 more
TL;DR: The study identified 78 transcripts that respond to sleep loss independent of corticosterone and time of day, among which genes involved in neuroprotection prominently feature, pointing to a molecular pathway directly relevant for sleep function.
Journal ArticleDOI
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1
Robbert Havekes,Robbert Havekes,Alan J. Park,Jennifer C. Tudor,Vincent Luczak,Rolf T. Hansen,Sarah L. Ferri,Vibeke M. Bruinenberg,Shane G. Poplawski,Jonathan P. Day,Sara J. Aton,Kasia Radwanska,Peter Meerlo,Miles D. Houslay,George S. Baillie,Ted Abel +15 more
TL;DR: This work demonstrates the necessity of an intact cAMP-PDE4-PKA-LIMK-cofilin activation-signaling pathway for sleep deprivation-induced memory disruption and reduction in hippocampal spine density.
Journal ArticleDOI
Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder.
Rodrigo Machado-Vieira,Giacomo Salvadore,David A. Luckenbaugh,Husseini K. Manji,Carlos A. Zarate +4 more
TL;DR: This article reviews the published data related to different aspects of rapid improvement of depressive symptoms and investigates whether certain experimental treatments can produce antidepressant response in a much shorter period of time than existing medications.
References
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Book
Psychopharmacology: The Fourth Generation of Progress
Floyd E. Bloom,David J. Kupfer +1 more
TL;DR: Part 1 Preclinical section: critical analysis of methods transmitter systems - amino acids, amines, peptides, new transmitterscritical analysis of integrative concepts.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
The Cumulative Cost of Additional Wakefulness: Dose-Response Effects on Neurobehavioral Functions and Sleep Physiology From Chronic Sleep Restriction and Total Sleep Deprivation
TL;DR: It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Journal ArticleDOI
Reactivation of hippocampal ensemble memories during sleep.
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.