Stabilization of β-catenin affects mouse embryonic liver growth and hepatoblast fate
Thomas Decaens,Thomas Decaens,Cécile Godard,Cécile Godard,Aurélien de Reyniès,David S. Rickman,François Tronche,Jean-Pierre Couty,Jean-Pierre Couty,Christine Perret,Christine Perret,Sabine Colnot,Sabine Colnot +12 more
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TLDR
A key role is demonstrated for the Wnt/β‐catenin pathway in liver embryonic growth and in controlling the fate of hepatoblasts, preventing them from differentiating toward the hepatocyte lineage, and guiding them to biliary ductal morphogenesis.About:
This article is published in Hepatology.The article was published on 2007-11-25 and is currently open access. It has received 147 citations till now. The article focuses on the topics: Hepatocyte differentiation & Wnt signaling pathway.read more
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
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Organogenesis and development of the liver.
TL;DR: The basic molecular mechanisms that control the formation of the liver as an organ are reviewed.
Journal ArticleDOI
Notch Signaling in Development, Tissue Homeostasis, and Disease
Chris Siebel,Urban Lendahl +1 more
TL;DR: The current understanding of how Notch signaling can become derailed, either by direct mutations or by aberrant regulation, and the expanding spectrum of diseases and cancers that is a consequence of Notch dysregulation are discussed.
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Cancer stem cells in the development of liver cancer
Taro Yamashita,Xin Wei Wang +1 more
TL;DR: An increased understanding of the molecular signaling events that regulate cellular hierarchy and stemness, and success in defining key CSC-specific genes, have opened up new avenues to accelerate the development of novel diagnostic and treatment strategies.
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Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9
Aline Antoniou,Peggy Raynaud,Sabine Cordi,Yiwei Zong,François Tronche,Ben Z. Stanger,Patrick Jacquemin,Christophe E. Pierreux,Frédéric Clotman,Frédéric P. Lemaigre +9 more
TL;DR: It is suggested that biliary development proceeds according to a new mode of tubulogenesis characterized by transient asymmetry and whose timing is controlled by SOX9.
References
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Journal ArticleDOI
Wnt/beta-catenin signaling in development and disease.
TL;DR: A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades, finding that Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
Journal ArticleDOI
Somatic mutations of the beta -catenin gene are frequent in mouse and human hepatocellular carcinomas
Alix de La Coste,Béatrice Romagnolo,Pierre Billuart,Claire-Angélique Renard,Marie-Annick Buendia,Olivier Soubrane,Monique Fabre,Jamel Chelly,Cherif Beldjord,Axel Kahn,Christine Perret +10 more
TL;DR: In this paper, the authors examined the status of the β-catenin gene in different transgenic mouse lines of HCC obtained with the oncogenes c-myc or H-ras.
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Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis.
Fereshteh Parviz,Christine M. Matullo,Wendy D. Garrison,Laura Savatski,John W. Adamson,Gang Ning,Klaus H. Kaestner,Jennifer M. Rossi,Kenneth S. Zaret,Stephen A. Duncan +9 more
TL;DR: It is reported that hepatocyte nuclear factor 4α (Hnf4α) is essential for morphological and functional differentiation of hepatocytes, accumulation of hepatic glycogen stores and generation of a hepatic epithelium, and the morphogenetic parameters controlled by Hnf 4α in hepatocytes are essential for normal liver architecture, including the organization of the sinusoidal endothelium.
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Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.
TL;DR: It is shown that complementation of HNF-4alpha embryos with a tetraploid embryo-derived wild-type visceral endoderm rescues this early developmental arrest and allows HNF -4alpha(-/-) embryos to proceed normally through midgestation stages of development, and concludes that H NF-4 alpha is both essential for hepatocyte differentiation during mammalian liver development and also crucial for metabolic regulation and liver function.
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Regulatory phases of early liver development: paradigms of organogenesis.
TL;DR: The acquisition of competence to express liver-specific genes by the endoderm, the control of early hepatic growth, the coordination of hepatic and vascular development and the cell differentiation that is necessary to generate a functioning liver are discussed.