Journal ArticleDOI
The interferon signature in autoimmune diseases.
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TLDR
The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.Abstract:
Purpose of reviewAn increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consread more
Citations
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The Multifaceted Functions of Neutrophils
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The multifaceted biology of plasmacytoid dendritic cells
Melissa Swiecki,Marco Colonna +1 more
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Cytokines in rheumatoid arthritis - shaping the immunological landscape.
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Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells
Jennifer Martinez,Larissa D. Cunha,Sunmin Park,Mao Yang,Qun Lu,Robert C. Orchard,Quan Zhen Li,Mei Yan,Laura J. Janke,Cliff Guy,Andreas Linkermann,Herbert W. Virgin,Douglas R. Green +12 more
TL;DR: In this paper, the authors describe the consequences of defective LC3-associated phagocytosis in vivo and show that mice lacking any of several components of the LAP pathway show increased serum levels of inflammatory cytokines and autoantibodies, glomerular immune complex deposition, and evidence of kidney damage.
References
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Journal ArticleDOI
Emerging Therapies for Systemic Lupus Erythematosus - Focus on Targeting Interferon-alpha
TL;DR: The multiple emerging treatment strategies targeting IFN α-related pathways are reviewed, including monoclonal antibodies against IFNα, anti-IFNα antibody-inducing vaccines, and inhibitors of Toll-like receptors.
Journal ArticleDOI
Association of the response to tumor necrosis factor antagonists with plasma type I interferon activity and interferon-β/α ratios in rheumatoid arthritis patients: A post hoc analysis of a predominantly Hispanic cohort
TL;DR: In this article, the authors investigated whether plasma type I IFN activity might predict response to tumor necrosis factor-α (TNF)-antagonist therapy in patients with rheumatoid arthritis.
Journal ArticleDOI
Importance of correlation between gene expression levels: application to the type I interferon signature in rheumatoid arthritis.
Frédéric Reynier,Fabien Petit,Malick Paye,Fanny Turrel-Davin,Pierre-Emmanuel Imbert,Arnaud Hot,Bruno Mougin,Pierre Miossec,Pierre Miossec +8 more
TL;DR: An original method to analyze genes sharing an expression pattern and a biological function showing that the activation levels of a biological signature could be characterized by its overall state of correlation is proposed.
Journal ArticleDOI
Disease Activity, Proteinuria, and Vitamin D Status in Children with Systemic Lupus Erythematosus and Juvenile Dermatomyositis
TL;DR: Serum 25(OH)D levels in subjects with SLE were inversely associated with the natural log of urinary DBP/C and urine protein to creatinine ratio and this relationship in SLE may be confounded by proteinuria.
Journal ArticleDOI
Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons
Rivka C. Stone,Di Feng,Jing Deng,Sukhwinder Singh,Lisong Yang,Patricia Fitzgerald-Bocarsly,Maija-Leena Eloranta,Lars Rönnblom,Betsy J. Barnes +8 more
TL;DR: This study provides the first formal proof that IRF-5 activation is altered in the monocytes of SLE patients, which can be attributed, in part, to the SLE blood environment.