Journal ArticleDOI
The interferon signature in autoimmune diseases.
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TLDR
The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.Abstract:
Purpose of reviewAn increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consread more
Citations
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The Multifaceted Functions of Neutrophils
TL;DR: Primordial neutrophil functions are discussed, and more recent evidence that interactions between neutrophils and adaptive immune cells establish a feed-forward mechanism that amplifies pathologic inflammation is presented.
Journal ArticleDOI
The multifaceted biology of plasmacytoid dendritic cells
Melissa Swiecki,Marco Colonna +1 more
TL;DR: Recent progress in the field of pDC biology is summarized, focusing on the molecular mechanisms that regulate the development and functions of p DCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.
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Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
TL;DR: The ability to therapeutically target intracellular signalling pathways has already created a new paradigm for the treatment of rheumatologic disease.
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Cytokines in rheumatoid arthritis - shaping the immunological landscape.
TL;DR: The combinatorial role played by cytokines in mediating the overlapping innate and adaptive immune responses associated with disease onset and persistence, and also those cytokine pathways that, in turn, drive the stromal response that is critical for tissue localization and associated articular damage are considered.
Journal ArticleDOI
Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells
Jennifer Martinez,Larissa D. Cunha,Sunmin Park,Mao Yang,Qun Lu,Robert C. Orchard,Quan Zhen Li,Mei Yan,Laura J. Janke,Cliff Guy,Andreas Linkermann,Herbert W. Virgin,Douglas R. Green +12 more
TL;DR: In this paper, the authors describe the consequences of defective LC3-associated phagocytosis in vivo and show that mice lacking any of several components of the LAP pathway show increased serum levels of inflammatory cytokines and autoantibodies, glomerular immune complex deposition, and evidence of kidney damage.
References
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Journal ArticleDOI
C1q Deficiency Leads to the Defective Suppression of IFN-α in Response to Nucleoprotein Containing Immune Complexes
Deanna M. Santer,Brian E. Hall,Thaddeus C. George,Stephanie Tangsombatvisit,Chih Long Liu,Peter D. Arkwright,Keith B. Elkon +6 more
TL;DR: In patients with C1q deficiency, serum and cerebrospinal fluid levels of IFN-α andIFN-γ–inducible protein-10 levels were elevated and strongly correlated with Ro autoantibodies, demonstrating the clinical significance of these observations.
Journal ArticleDOI
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
Timothy B. Niewold,Jennifer A. Kelly,Silvia N. Kariuki,Beverly S. Franek,Akaash A. Kumar,Kenneth M. Kaufman,Kenaz Thomas,Daniel Walker,Stan Kamp,Jacqueline Frost,Andrew Wong,Joan T. Merrill,Joan T. Merrill,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Mohammed Tikly,Rosalind Ramsey-Goldman,John D. Reveille,Michelle Petri,Jeffrey C. Edberg,Robert P. Kimberly,Graciela S. Alarcón,Diane L. Kamen,Gary S. Gilkeson,Timothy J. Vyse,Judith A. James,Judith A. James,Patrick M. Gaffney,Kathy L. Moser,Mary K. Crow,John B. Harley +30 more
TL;DR: A novel risk haplotype of IRF5 that is associated with anti-dsDNA antibodies is defined and it is shown that risk of SLE due to IRf5 genotype is largely dependent upon particular auto-antibodies.
Journal ArticleDOI
Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.
Maija-Leena Eloranta,Tanja Lövgren,Doreen Finke,Linda Mathsson,Johan Rönnelid,Berthold Kastner,Gunnar V. Alm,Lars Rönnblom +7 more
TL;DR: Investigating how IFNalpha production induced by RNA-containing immune complexes (ICs) in plasmacytoid dendritic cells (PDCs) is regulated found it is regulated by a network of interactions between monocytes, NK cells, and PDCs, involving several pro- and antiinflammatory molecules.
Journal ArticleDOI
Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment
Lisa G. M. van Baarsen,Lisa G. M. van Baarsen,Carla A. Wijbrandts,François Rustenburg,Tineke Cantaert,Tineke C. T. M. van der Pouw Kraan,Dominique Baeten,Ben A. C. Dijkmans,Paul P. Tak,Cornelis L. Verweij +9 more
TL;DR: In this paper, the effect of TNF blockade in rheumatoid arthritis (RA) on the type I IFN response gene activity in relation to clinical response was determined.
Journal ArticleDOI
Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon-α and atherosclerosis in lupus.
TL;DR: The data suggest that IFNα priming up-regulated the expression of SR-A in human monocyte/macrophages, leading to increased lipid uptake and foam cell formation, which is a crucial step in early atherosclerosis.