Journal ArticleDOI
The interferon signature in autoimmune diseases.
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TLDR
The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.Abstract:
Purpose of reviewAn increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consread more
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Journal ArticleDOI
The innate immune perspective of autoimmune and autoinflammatory conditions.
Shirly Frizinsky,Soad Haj-Yahia,Soad Haj-Yahia,Diti Machnes Maayan,Diti Machnes Maayan,Yulia Lifshitz,Yulia Lifshitz,Ramit Maoz-Segal,Ramit Maoz-Segal,Irean Offengenden,Mona Kidon,Mona Kidon,Nancy Agmon-Levin,Nancy Agmon-Levin +13 more
TL;DR: A myriad of diseases has been linked with innate immune dysregulation, particularly regarding autoinflammatory ones, and a mini-review of these conditions will shed some light on these conditions.
Journal ArticleDOI
Circulating Interferon-Inducible Protein IFI16 Correlates With Clinical and Serological Features in Rheumatoid Arthritis.
Alessia Alunno,Valeria Caneparo,Onelia Bistoni,Sara Caterbi,Riccardo Terenzi,Marisa Gariglio,Elena Bartoloni,Antonio Manzo,Santo Landolfo,Roberto Gerli +9 more
TL;DR: Clinical significance of both IFI16 protein and anti‐IFI16 antibodies in rheumatoid arthritis was investigated and leaking leads to loss of tolerance toward this self‐protein and the development of autoantibodies.
Journal ArticleDOI
T cells and cytokines in systemic sclerosis.
TL;DR: A better understanding of SSc pathogenesis will allow the development of novel therapeutic strategies targeting specific cell types and the pathways that are abnormally activated as well as the cytokines produced that may be directly involved with disease process.
Journal ArticleDOI
Type I Interferon Production of Plasmacytoid Dendritic Cells under Control.
TL;DR: In this paper, the authors summarize those endogenous factors that can influence the type I IFN responses of plasmacytoid dendritic cells (pDCs) and thus might serve as possible therapeutic targets in pDC-associated diseases.
Journal ArticleDOI
Clinical Aspects of Janus Kinase (JAK) Inhibitors in the Cardiovascular System in Patients with Rheumatoid Arthritis.
TL;DR: This review focused on the activity of JAK inhibitors in the cardiovascular system of patients with RA and placed special emphasis on the modification of heart performance, progression of atherosclerosis, lipid profile disturbance, and risk of thromboembolic complications.
References
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Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Journal ArticleDOI
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Journal ArticleDOI
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
TL;DR: Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease.
Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.