Journal ArticleDOI
The interferon signature in autoimmune diseases.
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TLDR
The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.Abstract:
Purpose of reviewAn increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consread more
Citations
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Journal ArticleDOI
Type I IFN Contributes to the Phenotype of Unc93b1D34A/D34A Mice by Regulating TLR7 Expression in B Cells and Dendritic Cells.
TL;DR: The roles of inflammatory cytokines such as IFN-γ, IL-17A, and type I IFNs are examined to understand the mechanism underlying the phenotype in D34A mice and it is suggested that these TLR7-expressing cells are activated initially and influence TLR 7-dependent systemic inflammation.
Journal ArticleDOI
Sjögren’s syndrome, should we sign?
TL;DR: Type I interferons (IFNs) play a significant role in the pathogenesis of primary Sjögren’s syndrome (pSS) and may contribute to overactivation of the innate and adaptive immune system, finally leading to B-cell hyperactivity, autoimmunity, and dysfunctioning of the glandular tissue.
Dissertation
Clinical and molecular characterization of the type I interferon signature in rheumatic diseases
TL;DR: The cover of this thesis symbolizes heterogeneity in rheumatoid arthritis: although all patients have swollen joints by definition, there are many interindividual differences, such as presence and absence of a type I IFN signature, and plenty other aspects that need much more PhD theses to be fully addressed.
Journal ArticleDOI
Jak Inhibitors for Treatment of Autoimmune Diseases: Lessons from Systemic Sclerosis and Systemic Lupus Erythematosus
TL;DR: The therapeutic potential of Jak kinases in light of the cytokine network that JAK kinases are able to interact with is discussed and the theoretical background for the rationale of blocking cytokines with specific JAK inhibitors is provided.
Journal ArticleDOI
A cluster of type II interferon-regulated genes associates with disease activity in patients with systemic lupus erythematosus.
K. Zahid Siddiqi,Amanda Hempel Zinglersen,Katrine Iversen,Niclas Stefan Rasmussen,Christoffer Tandrup Nielsen,Søren Jacobsen +5 more
TL;DR: In this article , the authors determined an IFN signature based on the expression of 128 interferon-regulated genes (IRGs) in whole blood from 34 systemic lupus erythematosus (SLE) patients in a cross-sectional (CS) study.
References
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Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Journal ArticleDOI
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Journal ArticleDOI
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
TL;DR: Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease.
Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.