Journal ArticleDOI
The interferon signature in autoimmune diseases.
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TLDR
The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.Abstract:
Purpose of reviewAn increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consread more
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CCK8 negatively regulates the TLR9-induced activation of human peripheral blood pDCs by targeting TRAF6 signaling
TL;DR: Results indicate that CCK8 can inhibit the TLR9‐induced phenotypic maturation and activation of pDCs, acting through CCK2R by modulating the tumor‐necrosis factor receptor‐associated factor 6 signaling pathways.
Journal ArticleDOI
Biomarkers for Childhood-Onset Systemic Lupus Erythematosus
TL;DR: Novel biomarkers for cSLE include cell-bound complement activation products, some genomic profiles, and urinary proteins such as neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and others which can be used for monitoring disease activity and response to treatment.
Journal ArticleDOI
Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles.
John A. Reynolds,John A. Reynolds,Tracy A Briggs,Tracy A Briggs,Gillian I. Rice,Sathya Darmalinggam,Vincent Bondet,Vincent Bondet,Ellen Bruce,Mumtaz Khan,Sahena Haque,Hector Chinoy,Ariane L. Herrick,Eoghan M. McCarthy,Leo A. H. Zeef,Andrew Hayes,Darragh Duffy,Darragh Duffy,Ben Parker,Ben Parker,Ian N. Bruce,Ian N. Bruce +21 more
TL;DR: In SARD patients, IFNα-positivity was associated with specific autoantibodies and haematological parameters but not with other clinical features, and the variable NAR expression suggests that different pathways may drive IFN α production in individual patients.
Journal ArticleDOI
Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus
Hui Luo,Ling Wang,Ding Bao,Li Wang,Hongjun Zhao,Yun Lian,Mei Yan,Chandra Mohan,Quan Zhen Li,Quan Zhen Li +9 more
TL;DR: Molecular interaction network analysis revealed that the antigens targeted by the autoAbs were most significantly enriched in cell death, cell cycle, and DNA repair pathways, which may shed light on potential pathogenic pathways leading to lupus.
Journal ArticleDOI
Dysregulated innate immune function in the aetiopathogenesis of idiopathic inflammatory myopathies.
Jessica Day,Jessica Day,Sophia Otto,Susanna Proudman,Susanna Proudman,John D. Hayball,John D. Hayball,Vidya Limaye,Vidya Limaye +8 more
TL;DR: The traditional paradigms of IIM pathogenesis are summarised and the accumulating evidence for disturbances in innate immune processes in these rare, but debilitating chronic conditions is reviewed.
References
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Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Journal ArticleDOI
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Journal ArticleDOI
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
TL;DR: Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease.
Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.