Journal ArticleDOI
The interferon signature in autoimmune diseases.
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TLDR
The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.Abstract:
Purpose of reviewAn increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consread more
Citations
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Journal ArticleDOI
Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.
Faye A. H. Cooles,Faye A. H. Cooles,Amy E. Anderson,Amy E. Anderson,Andrew J. Skelton,Andrew J. Skelton,Arthur G. Pratt,Arthur G. Pratt,Mariola Kurowska-Stolarska,Iain B. McInnes,Catharien M. U. Hilkens,Catharien M. U. Hilkens,John D. Isaacs,John D. Isaacs +13 more
TL;DR: This is the first detailed examination of DC subsets in eRA peripheral blood and suggests pDCs are less activated and may be skewed toward tolerogenic functions, whereas for CD1c+ DCs, pro-inflammatory transcripts were upregulated.
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Epidemiology of Sjögren's Syndrome-from an Oral Perspective.
TL;DR: An update on oral aspects of Sjögren’s syndrome with emphasis on the latest publications on the proposed biomarkers of active disease, including the interferon signature, the Interferon γ/interferon α mRNA ratio, and CXCL13 are provided.
Journal ArticleDOI
Extracellular dsRNA: its function and mechanism of cellular uptake.
TL;DR: This review presents an overview of double-stranded RNA, addressing its roles in infection, autoimmunity, and host sensing mechanisms, with a focus on extracellular recognition and uptake by the cell.
Journal ArticleDOI
Ocular fluid analysis in children reveals interleukin‐29/interferon‐λ1 as a biomarker for juvenile idiopathic arthritis associated uveitis
Anne-Mieke J. W. Haasnoot,Jonas J.W. Kuiper,Sanne Hiddingh,Peter A W J F Schellekens,Wilco de Jager,Saskia M. Imhof,Timothy R D J Radstake,Joke H. de Boer +7 more
TL;DR: In this article, the authors analyzed soluble mediators in ocular fluid (aqueous humor; AqH) and serum of children with JIA associated uveitis (JIA-U) and common childhood Uveitis to identify potential biomarkers and investigate the ocular micro-environment of this sight-threatening eye disease.
Journal ArticleDOI
Autoantibody Specificities and Type I Interferon Pathway Activation in Idiopathic Inflammatory Myopathies
Louise Ekholm,Saskia Vosslamber,Anna Tjärnlund,T. D. de Jong,Zoe E Betteridge,Neil McHugh,L. Pleštilová,Martin Klein,Leonid Padyukov,Alexandre E. Voskuyl,Irene E. M. Bultink,D. Michiel Pegtel,Clio P. Mavragani,Mary K. Crow,Jiri Vencovsky,Ingrid E. Lundberg,Cornelis L. Verweij +16 more
TL;DR: These studies identify IFN‐α in sera as a trigger for activation of the type I IFN pathway in peripheral blood and support IFN-α as a possible target for therapy in patients with myositis.
References
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Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Journal ArticleDOI
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Journal ArticleDOI
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
TL;DR: Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease.
Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.