Journal ArticleDOI
The interferon signature in autoimmune diseases.
Reads0
Chats0
TLDR
The observed IFN signature in several autoimmune diseases is a biomarker of active disease and is investigated as a tool when selecting treatment for individual patients.Abstract:
Purpose of reviewAn increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consread more
Citations
More filters
Journal ArticleDOI
Editorial: The Silent Cry: How to Turn Translational Medicine Towards Patients and Unmet Medical Needs.
Journal ArticleDOI
High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells
Kensei Kishimoto,Catera L. Wilder,Justin Buchanan,Minh Tan Nguyen,Chidera Okeke,Chidera Okeke,Alexander Hoffmann,Quen J. Cheng +7 more
TL;DR: In this article, high doses of IFN-β signaling activate both ISGF3 and GAF, which bind to distinct genomic locations defined by their respective DNA sequence motifs.
Journal ArticleDOI
Meta-Analysis of Polymyositis and Dermatomyositis Microarray Data Reveals Novel Genetic Biomarkers.
Jaeseung Song,Daeun Kim,Juyeon Hong,Go Woon Kim,Junghyun Jung,Sejin Park,Hee Jung Park,Jong Wha J. Joo,Wonhee Jang +8 more
TL;DR: Along with previously reported genes, 4 novel genes and 10 SNP-variant regions which could be used as candidates for potential drug targets or biomarkers for PM and DM are identified.
Journal ArticleDOI
Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Javier Rodríguez-Carrio,Agata Burska,P.G. Conaghan,Willem A. Dik,Robert Biesen,Maija-Leena Eloranta,Giulio Cavalli,Marianne de Visser,Dimitrios T. Boumpas,George Bertsias,Marie Wahren-Herlenius,Jan Rehwinkel,Marie-Louise Frémond,Mary K. Crow,L. Ronnblom,Edward M Vital,Marjan A. Versnel +16 more
TL;DR: A systematic literature review was conducted across three databases to evaluate the use of IFN-I assays in diagnosis and monitor disease activity, prognosis, response to treatment and responsiveness to change in several rheumatic and musculoskeletal diseases as discussed by the authors .
Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases
TL;DR: Primary Sjogren’s syndrome (pSS) and systemic lupu ...
References
More filters
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
Journal ArticleDOI
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Journal ArticleDOI
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
Roberto Lande,Josh Gregorio,Valeria Facchinetti,Bithi Chatterjee,Bithi Chatterjee,Yi Hong Wang,Bernhard Homey,Wei Cao,Yui-Hsi Wang,Bing Su,Frank O. Nestle,Tomasz Zal,Ira Mellman,Ira Mellman,Jens-Michael Schröder,Yong-Jun Liu,Michel Gilliet +16 more
TL;DR: The data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.
Journal ArticleDOI
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
TL;DR: Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease.
Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.