The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity.
TLDR
This mini review underlines the potential of the zebrafish as complementary models for developmental neurotoxicity screening of chemicals and describes the different endpoints utilized for such screening with some studies illustrating their use.Abstract:
The developing central nervous system and the blood brain barrier are especially vulnerable and sensitive to different chemicals, including environmental contaminants and drugs. Developmental exposure to these compounds has been involved in several neurological disorders, such as autism spectrum disorders as well as Alzheimer's and Parkinson's diseases. Zebrafish (Danio Rerio) have emerged as powerful toxicological model systems that can speed up chemical hazard assessment and can be used to extrapolate neurotoxic effects that chemicals have on humans. Zebrafish embryos and larvae are convenient for high-throughput screening of chemicals, due to their small size, low-cost, easy husbandry, and transparency. Additionally, zebrafish are homologous to other higher order vertebrates in terms of molecular signaling processes, genetic compositions, and tissue/organ structures as well as neurodevelopment. This mini review underlines the potential of the zebrafish as complementary models for developmental neurotoxicity screening of chemicals and describes the different endpoints utilized for such screening with some studies illustrating their use.read more
Citations
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Journal ArticleDOI
Use of Zebrafish in Drug Discovery Toxicology
Steven Cassar,Isaac Adatto,Jennifer L. Freeman,Joshua T. Gamse,Iñaki Iturria,Christian Lawrence,Arantza Muriana,Randall T. Peterson,Steven Van Cruchten,Leonard I. Zon +9 more
TL;DR: The zebrafish model is a bridge between in vitro assays and mammalian in vivo studies, which is powerful in its breadth of application and tractability for research, and the 3Rs value that it can deliver is discussed.
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Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants.
TL;DR: The goal of this review was to develop a link to ethnopharmacological zebrafish studies that can be used by other researchers to conduct future research and highlight its power as a tool for detecting toxicity of medicinal plants and its effectiveness at enhancing the understanding of new drug generation.
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Approaches to Test the Neurotoxicity of Environmental Contaminants in the Zebrafish Model: From Behavior to Molecular Mechanisms.
TL;DR: In this article, the authors highlight approaches ranging from behavioral to structural, functional, and molecular analysis of the larval zebrafish nervous system, providing a holistic view of potential neurotoxic outcomes.
Journal ArticleDOI
Zebrafish as a Model of Neurodevelopmental Disorders
Murilo S. de Abreu,Rafael Genario,Ana C.V.V. Giacomini,Konstantin A. Demin,Anton M. Lakstygal,Tamara G. Amstislavskaya,Barbara D. Fontana,Matthew O. Parker,Allan V. Kalueff,Allan V. Kalueff +9 more
TL;DR: Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs with high physiological homology to humans and sensitivity to pharmacological and genetic manipulations.
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Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae.
Jie Gu,Guo Min,Caoxing Huang,Xi Wang,Yuanhui Zhu,Lei Wang,Zhen Wang,Linjun Zhou,Deling Fan,Lili Shi,Guixiang Ji +10 more
TL;DR: It is demonstrated that early-life stage exposure of zebrafish to nano-TiO2 causes adverse neural outcomes through the inhibition of neurodevelopment and motor neuron axonal growth.
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Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond
Allan V. Kalueff,Michael Gebhardt,Adam Stewart,Adam Stewart,Jonathan Cachat,Mallorie Brimmer,Jonathan S Chawla,Cassandra Craddock,Evan J. Kyzar,Andrew Roth,Samuel Landsman,Siddharth Gaikwad,Kyle Robinson,Erik Baatrup,Keith B. Tierney,Angela L. Shamchuk,William H. J. Norton,Noam Miller,Teresa Nicolson,Oliver Braubach,Charles P. Gilman,Julian Pittman,Denis B. Rosemberg,Robert Gerlai,David J. Echevarria,Elisabeth Lamb,Stephan C.F. Neuhauss,Wei Weng,Laure Bally-Cuif,Henning Schneider +29 more
TL;DR: A detailed catalog of zebrafish behaviors that covers both larval and adult models is developed, representing a beginning of creating a more comprehensive ethogram ofZebrafish behavior, which will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebra fish neurobehavioral paradigms in their research.
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TL;DR: Eviologic investigations focused on nongenetic factors have established advanced parental age and preterm birth as ASD risk factors, indicated that prenatal exposure to air pollution and short interpregnancy interval are potentialrisk factors, and suggested the need for further exploration of certain prenatal nutrients, metabolic conditions, and exposure to endocrine-disrupting chemicals.
Journal ArticleDOI
Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children.
TL;DR: Exposure to prenatal tobacco and environmental lead are risk factors for ADHD in U.S. children, and if causally linked, these data suggest that prenatal tobacco exposure accounts for 270,000 excess cases of ADHD, and lead Exposure accounts for 290,000 extra cases of ADD.
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TL;DR: The findings discussed indicate that identification of environmental chemicals that dysregulate the prenatal epigenome should be a priority in health research and disease prevention.
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