Journal ArticleDOI
Transferrin and transferrin receptors update.
TLDR
An update and summary on the knowledge of mammalian Tf and its receptors is provided and apo‐Tf has been explored for various clinical conditions including atransferrinemia, iron overload, and tissue ischemia.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2019-03-01. It has received 286 citations till now. The article focuses on the topics: Transferrin receptor & Transferrin.read more
Citations
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Iron homeostasis and oxidative stress: An intimate relationship
TL;DR: This review focuses on the intimate relationship between iron metabolism and oxidative stress in health and disease, and discusses aspects of redox- and iron-mediated signaling, toxicity, ferroptotic cell death, homeostatic pathways and pathophysiological implications.
Journal ArticleDOI
The multifaceted role of iron in renal health and disease.
TL;DR: Targeting mechanisms of local and systemic iron homeostasis may provide novel therapies for kidney disease and its complications, including anaemia; however, such approaches will require close monitoring of iron balance and potential adverse effects.
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
TL;DR: In this paper, the expression of iron related molecules in the liver, duodenum, and spleen of homozygous TfR2-KO, heterozygous, and wild-type mice were analyzed using real-time polymerase chain reaction.
Journal ArticleDOI
Ferritin drug carrier (FDC) for tumor targeting therapy.
TL;DR: Compared with antibody-drug conjugates (ADCs), ferritin exhibits superiority in a range of attributes, including drug loading ability, thermostability, and ease of production, and the emergence of FDCs may be the next step in targeted cancer therapy.
References
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Journal ArticleDOI
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
TL;DR: It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver *
TL;DR: Hepcidin may be a vertebrate counterpart of cysteine-rich antimicrobial peptides produced in the fat body of insects and exhibited antifungal activity against Candida albicans, Aspergillus fumigatus, and As pergillus nigerand antibacterial activity against Escherichia coli.
Journal ArticleDOI
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
Christelle Pigeon,Gennady Ilyin,Brice Courselaud,Patricia Leroyer,Bruno Turlin,Pierre Brissot,Olivier Loréal +6 more
TL;DR: The data strongly suggest that the product of the new liver-specific gene HEPC might play a specific role during iron overload and exhibit additional functions distinct from its antimicrobial activity.
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Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more