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Journal ArticleDOI

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

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TLDR
The occurrence and risk factors for OA are reviewed and patient-reported outcome measures that have been used for the assessment of the disease are considered.
Abstract
Osteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and spine are the most commonly affected sites. Knowledge about the occurrence and risk factors for OA is important to define the clinical and public health burden of the disease to understand mechanisms of disease occurrence and may also help to inform the development of population-wide prevention strategies. In this article, we review the occurrence and risk factors for OA and also consider patient-reported outcome measures that have been used for the assessment of the disease.

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Citations
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Journal ArticleDOI

Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019

TL;DR: To estimate systematic and anatomic site–specific age-specific age‐standardized prevalence rates (ASRs) and analyze the secular trends of osteoarthritis at global, regional, and national levels, a database of known and suspected cases of OA is analyzed.
Journal ArticleDOI

The Role of Autophagy in Osteoarthritis.

TL;DR: The relationship between Autophagy and OA and the key molecules of autophagy pathway that regulate the progression of OA are explored, providing new ideas for OA treatment by targeting autophagic.
Journal ArticleDOI

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

TL;DR: Osteoarthitis is the most common aging-related joint pathology; the aging process results in changes to joint tissues that ultimately contribute to the development of OA and resveratrol can activate SIRT 1 in order to inhibit OA disease progression.
Journal ArticleDOI

Early-stage symptomatic osteoarthritis of the knee - time for action

TL;DR: In this article, the authors identified and defined symptomatic early-stage OA of the knee (the focus of this review) urgently needs to be identified, as efficient early stage case finding and diagnosis in primary care would enable health care providers to proactively and substantially reduce the burden of disease through proper management including structured education, exercise and weight management (when needed) and addressing lifestyle-related risk factors for disease progression.
Journal ArticleDOI

Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis

TL;DR: It is found that treatment with rapamycin (a selective mTOR inhibitor) also exerts chondro-protective effects that ameliorate OA by promoting autophagy, suggesting that inhibition of the mTOR pathway could be exploited for therapeutic benefits in the treatment of OA.
References
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Journal ArticleDOI

Radiological Assessment of Osteo-Arthrosis

TL;DR: It was concluded that, to ensure maximum uniformity in grading x rays in field surveys and therapeutic trials, all readings should be made by the same observer, preferably at a single session.
Journal Article

Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.

TL;DR: WOMAC is a disease-specific purpose built high performance instrument for evaluative research in osteoarthritis clinical trials and fulfil conventional criteria for face, content and construct validity, reliability, responsiveness and relative efficiency.
Journal ArticleDOI

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Theo Vos, +363 more
- 15 Dec 2012 - 
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal Article

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 (vol 380, pg 2197, 2012)

TL;DR: In this article, a comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study, and the authors aimed to calculate disease burden globally and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.
Journal ArticleDOI

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Christopher J L Murray, +369 more
- 15 Dec 2012 - 
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
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What are the most common locations for osteoarthritis of the knee?

The knee is one of the most commonly affected sites for osteoarthritis.