Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Emanuela Pasciuto,Oliver T. Burton,Carlos P. Roca,Vasiliki Lagou,Wenson D. Rajan,Tom Theys,Renzo Mancuso,Raul Y. Tito,Lubna Kouser,Zsuzsanna Callaerts-Vegh,Alerie Guzman de la Fuente,Teresa Prezzemolo,Loriana G. Mascali,Aleksandra Brajic,Carly E. Whyte,Lidia Yshii,Anna Martínez-Muriana,Michelle Naughton,Andrew Young,Alena Moudra,Pierre Lemaitre,Suresh Poovathingal,Jeroen Raes,Bart De Strooper,Bart De Strooper,Denise C. Fitzgerald,James Dooley,Adrian Liston,Adrian Liston +28 more
TLDR
A role for CD4 T cells in brain development and a potential interconnected dynamic between the evolution of the immunological and neurological systems are illuminated.About:
This article is published in Cell.The article was published on 2020-08-06 and is currently open access. It has received 158 citations till now. The article focuses on the topics: Population & Immune privilege.read more
Citations
More filters
Journal ArticleDOI
The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology.
TL;DR: The status of the knowledge and the open questions in the field focusing on the function of intestinal microbial metabolites or products on CNS cells during healthy and inflammatory conditions, such as multiple sclerosis, Alzheimer's and Parkinson’s diseases, and also neuropsychiatric disorders are discussed.
Journal ArticleDOI
Microglia states and nomenclature: A field at its crossroads
Rosa C. Paolicelli,Amanda Sierra,Beth Stevens,Marie-Ève Tremblay,Adriano Aguzzi,Bahareh Ajami,Ido Amit,Etienne Audinat,Ingo Bechmann,Mariko L. Bennett,Frederick Joseph Bennett,Alain Bessis,Knut Biber,Staci D. Bilbo,Mathew Blurton-Jones,Erik Boddeke,Dora Brites,Bert Brône,Guy C. Brown,Oleg Butovsky,Monica J. Carson,Bernardo Castellano,Marco Colonna,Sally A. Cowley,Colm Cunningham,Dimitrios Davalos,Philip L. De Jager,Bart De Strooper,Adam Denes,Bart J. L. Eggen,Ukpong B. Eyo,Elena Galea,Sonia Garel,Florent Ginhoux,Christopher K. Glass,Ozgun Gokce,Diego Gomez-Nicola,Berta González,Siamon Gordon,Manuel B. Graeber,Andrew D. Greenhalgh,Pierre Gressens,Melanie Greter,David H. Gutmann,Christian Haass,Michael T. Heneka,Frank L. Heppner,Soyon Youngae Hong,David Hume,Steffen Jung,Helmut Kettenmann,Jonathan Kipnis,Ryuta Koyama,Greg Lemke,Marina A. Lynch,Ania K. Majewska,Marzia Malcangio,Tarja Malm,Renzo Mancuso,Takahiro Masuda,Michela Matteoli,Barry W. McColl,Veronique E. Miron,Anna V. Molofsky,Michelle Monje,Eva Mracsko,Agnès Nadjar,Jonas J. Neher,Urte Neniskyte,Harald Neumann,Mami Noda,Bo Peng,Francesca Peri,V. Hugh Perry,Phillip G. Popovich,Clare Pridans,Josef Priller,Marco Prinz,Davide Ragozzino,Richard M. Ransohoff,Michael W. Salter,Anne Schaefer,Dorothy A. Schafer,Michal Schwartz,Mikael Simons,Cody Smith,Wolfgang J. Streit,Tuan Leng Tay,Li-Huei Tsai,Alexei Verkhratsky,Rommy von Bernhardi,Hiroaki Wake,Valérie Wittamer,Susanne A. Wolf,Longyan Wu,Tony Wyss-Coray +95 more
TL;DR: A conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors are discussed in this article . But, as mentioned before, the proposed framework does not consider the role of functional microglia in development, plasticity, aging, and diseases.
Journal ArticleDOI
Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation
TL;DR: The immune system of the central nervous system (CNS) consists primarily of innate immune cells, which are highly specialized macrophages found either in the parenchyma, called microglia, or at the CNS interfaces, such as leptomeningeal, perivascular, and choroid plexus macrophage as mentioned in this paper.
Journal ArticleDOI
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Cameron S. McAlpine,Cameron S. McAlpine,Joseph Park,Ana Griciuc,Eunhee Kim,Se Hoon Choi,Yoshiko Iwamoto,M. Kiss,Kathleen A. Christie,Claudio Vinegoni,Wolfram C. Poller,Wolfram C. Poller,John E. Mindur,Christopher T. Chan,Shun He,Henrike Janssen,Lai Ping Wong,Jeffrey Downey,Sumnima Singh,Atsushi Anzai,Florian Kahles,Mehdi Jorfi,Paolo Fumene Feruglio,Ruslan I. Sadreyev,Ralph Weissleder,Benjamin P. Kleinstiver,Matthias Nahrendorf,Rudolph E. Tanzi,Filip K. Swirski,Filip K. Swirski +29 more
TL;DR: In this paper, it was shown that interleukin-3 signalling from astrocytes to microglia is a key mediator of cross-talk and a node for therapeutic intervention in Alzheimer's disease.
Journal ArticleDOI
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
Samuel E. Marsh,Alec J. Walker,Tushar Kamath,Lasse Dissing-Olesen,Timothy R. Hammond,T. Yvanka de Soysa,Adam Young,Sarah Murphy,Abdulraouf Abdulraouf,Naeem Nadaf,Connor Dufort,Alicia C. Walker,Liliana E. Lucca,Velina Kozareva,Charles R. Vanderburg,Soyon Youngae Hong,Harry Bulstrode,Peter J. Hutchinson,Daniel J. Gaffney,David A. Hafler,Robin J.M. Franklin,Evan Z. Macosko,Beth Stevens +22 more
TL;DR: In this paper , the authors demonstrate that enzymatic dissociation on brain tissue induces an aberrant ex vivo gene expression signature, most prominently in microglia, which is prevalent in published literature and can substantially confound downstream analyses.
References
More filters
Journal Article
R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
Journal ArticleDOI
DADA2: High-resolution sample inference from Illumina amplicon data
Benjamin J. Callahan,Paul J. McMurdie,Michael J. Rosen,Andrew W. Han,Amy Jo A. Johnson,Susan Holmes +5 more
TL;DR: The open-source software package DADA2 for modeling and correcting Illumina-sequenced amplicon errors is presented, revealing a diversity of previously undetected Lactobacillus crispatus variants.
Journal ArticleDOI
phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.
Paul J. McMurdie,Susan Holmes +1 more
TL;DR: The phyloseq project for R is a new open-source software package dedicated to the object-oriented representation and analysis of microbiome census data in R, which supports importing data from a variety of common formats, as well as many analysis techniques.
Related Papers (5)
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more