E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
Papers
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Journal ArticleDOI
Erythropoietin, Modified to Not Stimulate Red Blood Cell Production, Retains Its Cardioprotective Properties
Chanil Moon,Melissa Krawczyk,Doo-Jin Paik,Thomas Coleman,Michael Brines,Magdalena Juhaszova,Steven J. Sollott,Edward G. Lakatta,Mark I. Talan +8 more
TL;DR: The antiapoptotic cardioprotective effects of CEPO, shown by its ability to limit both post-MI left ventricular remodeling and the extent of the myocardial scar in the model of permanent coronary artery ligation in rats, demonstrate comparable potency to that of native (nonmodified) EPO.
Journal Article
Do hypertension and aging have a similar effect on the myocardium
TL;DR: Myocardial hypertrophy does not appear to be the common link between cellular changes due to aging and those due to hypertension.(ABSTRACT TRUNCATED at 250 WORDS)
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Pulse wave velocity is associated with muscle mass decline: Health ABC study
Angela Marie Abbatecola,Paolo Chiodini,Ciro Gallo,Edward G. Lakatta,Kim Sutton-Tyrrell,Frances A. Tylavsky,Bret H. Goodpaster,Natalie De Rekeneire,Ann V. Schwartz,Giuseppe Paolisso,Tamara B. Harris +10 more
TL;DR: In older persons, arterial stiffening is associated with skeletal muscle mass decline differently for race and gender, and the association between PWV and muscle parameters after adjusting for confounders is determined.
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Chronic Matrix Metalloproteinase Inhibition Retards Age-associated Arterial Proinflammation and Increase in Blood Pressure
Mingyi Wang,Jing Zhang,Richard Telljohann,Liqun Jiang,James Wu,Robert E. Monticone,Kapil Kapoor,Mark I. Talan,Edward G. Lakatta +8 more
TL;DR: It is indicated that MMP inhibition retards age-associated arterial proinflammatory signaling, and this is accompanied by preservation of intact elastin fibers, a reduction in collagen, and blunting of an age- associated increase in blood pressure.
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The Conundrum of Arterial Stiffness, Elevated Blood Pressure, and Aging
Majd AlGhatrif,Edward G. Lakatta +1 more
TL;DR: The complex nature of the hemodynamic changes with aging makes the “one-size-fits-all” approach suboptimal and urges for therapies that address the vascular profile that underlies a given blood pressure, rather than the blood pressure values themselves.