E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Ion concentration-dependence of rat cardiac unitary L-type calcium channel conductance
TL;DR: It was found that quasi-physiological concentrations of Ca produced currents that were as easily resolvable as those obtained with the traditionally used higher concentrations, and this study leads to future work on the molecular basis of E-C coupling with a physiological concentration of Ca ions permeating the Ca channel.
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Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?
TL;DR: Colocalization of PDE3 and PDE4 beneath sarcolemma or in striated patterns inside SANCs strongly suggests that PDE-dependent regulation of cAMP/PKA signaling might be executed at the local level; this idea, however, requires further verification.
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Electromechanical responsiveness of hyperthyroid cardiac muscle to beta-adrenergic stimulation.
TL;DR: The results suggest that beta-adrenergic stimulation appears to have a "dual" relaxant effect on the myocardium because factors through which catecholamines enhance the rate of tension decay in the terminal phase of the contraction cycle are independent of those that reduce TPT and RT 1/2.
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Age-associated cardiovascular changes are the substrate for poor prognosis with myocardial infarction.
TL;DR: The authors showed that advanced age is a powerful independent predictor of short-term mortality and morbidity in post-infarct patients, including 10-fold increases in death, clinical heart failure (HF), and cardiogenic shock as age increases from 85.
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Impact of T2 decay on carotid artery wall thickness measurements
Ye Qiao,David A. Steinman,Maryam Etesami,Alex Martinez-Marquese,Edward G. Lakatta,Bruce A. Wasserman +5 more
TL;DR: To investigate the impact of T2 relaxation of the carotid wall on measurements of its thickness, a high-performance liquid chromatography method is used.