E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
Papers
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Journal ArticleDOI
Effects of acute beta-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise.
Jerome L. Fleg,Steven P. Schulman,Frances C. O'Connor,L. C. Becker,Gary Gerstenblith,J. F. Clulow,Dale G. Renlund,Edward G. Lakatta +7 more
TL;DR: In this article, the nonselective beta-adrenergic receptor blocker propranolol (0.15 mg/kg IV) was administered to 25 healthy normotensive men from the Baltimore Longitudinal Study of Aging (BLSA) immediately before maximal upright cycle ergometry with 99mTc gated cardiac blood pool scintigraphy.
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Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements
Hidetaka Hougaku,Jerome L. Fleg,Samer S. Najjar,Edward G. Lakatta,S. Mitchell Harman,Marc R. Blackman,E. Jeffrey Metter,E. Jeffrey Metter +7 more
TL;DR: The adverse influence of low T on the cardiovascular system in men may be mediated in part via the effects of T on vascular structure and function.
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The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development
Huang-Tian Yang,David Tweedie,Su Wang,Antonio Guia,Tatiana M. Vinogradova,Konstantin Y. Bogdanov,Paul D. Allen,Michael D. Stern,Edward G. Lakatta,Kenneth R. Boheler +9 more
TL;DR: It is concluded that a functional RyR2 is crucial to the progressive increase in heart rate during differentiation of ES cell-derived cardiomyocytes, consistent with a mechanism that couples Ca2+ release via RyR before an action potential with activation of an inward current that accelerates membrane depolarization.
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Central versus ambulatory blood pressure in the prediction of all-cause and cardiovascular mortalities.
Chi Ming Huang,Kang Ling Wang,Hao Min Cheng,Shao Yuan Chuang,Shih Hsien Sung,Wen Chung Yu,Chih Tai Ting,Edward G. Lakatta,Frank C.P. Yin,Pesus Chou,Chen Huan Chen +10 more
TL;DR: Out-of-office ambulatory peripheral blood pressure (SBP- 24 h) may be superior to central blood pressure in the prediction of cardiovascular mortality, but PP-C may better predict all-cause mortality than SBP-24 h or PP-24h.
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Beneficial Effects of Chronic Pharmacological Manipulation of β-Adrenoreceptor Subtype Signaling in Rodent Dilated Ischemic Cardiomyopathy
Ismayil Ahmet,Melissa Krawczyk,Phillip F. Heller,Chanil Moon,Edward G. Lakatta,Mark I. Talan +5 more
TL;DR: These results provide proof of concept for the efficacy of chronic &bgr;2AR stimulation in this DCM model and protect myocytes from death and thereby ameliorate cardiac remodeling in chronic heart failure.