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Edward G. Lakatta

Researcher at National Institutes of Health

Publications -  902
Citations -  95504

Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.

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Journal ArticleDOI

Ischemic preconditioning increases the bioavailability of cardiac enkephalins

TL;DR: IPC appears to increase available bioactive enkephalins (MEAP + ME) within the heart by enhancing synthesis of precursors and their subsequent processing from the larger proenkephalin precursor (PEP) pool.
Book ChapterDOI

Spontaneous sarcoplasmic reticulum Ca2+ release leads to heterogeneity of contractile and electrical properties of the heart.

TL;DR: S-CaOs may be implicated in diverse manifestations of heart failure--impaired systolic performance, increased diastolic tonus and an increased probability for the occurrence of arrhythmias.
Journal ArticleDOI

Dilated cardiomyopathy with increased SR Ca2+ loading preceded by a hypercontractile state and diastolic failure in the α1CTG mouse

TL;DR: It is demonstrated that older NFTG myocytes exhibit a hypercontractile state over a wide range of stimulation frequencies, but maintain a normal SR Ca2+ load compared to age matched non-transgenic (NTG) myocytes, but at high stimulation rates signs of diastolic contractile failure appear in N FTG cells.