E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Risk factors for exercise-induced silent myocardial ischemia in healthy volunteers☆
Leslie I. Katzel,John D. Sorkin,Eric Colman,Andrew P. Goldberg,M.Janette Busby-Whitehead,Loretta E. Lakatta,Lewis C. Becker,Edward G. Lakatta,Jerome L. Fleg +8 more
TL;DR: Older age, male gender, abdominal obesity, and reduced HDL levels--all well-established risk factors for overt CAD--were risk Factors for exercise-induced silent ischemia in these asymptomatic volunteers.
Journal ArticleDOI
Mechanisms of hypertension in the elderly.
TL;DR: The purported mechanisms underlying age‐associated changes in the cardiovascular system of normotensive individuals that could plausibly interact with these pathophysiologic mechanisms of hypertension are reviewed.
Journal ArticleDOI
Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium.
Carlo Ventura,R Miller,H P Wolf,N Beier,Richard A. Jonas,M Klockow,I Lues,O Hano,Harold A. Spurgeon,Edward G. Lakatta +9 more
TL;DR: Investigation of the effects and mechanism of action of novel diazinone derivatives on guinea pig myocardial preparations indicates that structural changes in the d Diazinone molecule shift the mechanism ofaction for the positive inotropic effect of the diazInone derivatives in the intact cell from a predominant myofilament sensitization to an enhancement in cell Ca2+ loading and an augmentation in the Cai transient (EMD 54650).
Journal ArticleDOI
The Pressure of Aging
TL;DR: There is an increased prevalence of salt-sensitive hypertension with advancing age that is, in part, mediated by marinobufagenin, an endogenous sodium pump ligand.