Edward G. Lakatta

TL;DR: Examination of changes in the expression of membrane-type metalloproteinase (MT-MMP-1) and activation of MMP-2 in rat carotid arteries subjected to balloon catheter injury shows that increased expression of MT-M MP-1 occurs early after injury to the ratCarotid artery and that at later times M MP-2 is preferentially localized to the developing neointima.

TL;DR: Understanding the adaptive mechanisms of Ca(2+) regulation in hibernating mammals may suggest new strategies to protect nonhibernator cells, including those of humans, from Ca( 2+)-induced dysfunction.

TL;DR: Data suggest that individual myocyte function may be preserved but that myocyte loss and replacement by extracellular matrix contribute substantially to the decrement in active tension, and research opportunities include investigation of apoptosis as a mechanism of cell loss and delineation of the regulatory roles of TGF-beta 1 and the renin-angiotensin-aldosterone system in matrix accumulation.

TL;DR: In pertussis toxin-treated cells, although the response of cAMP was not altered, the beta 2-AR-stimulated increase in contraction amplitude was markedly enhanced and accompanied by a hastened relaxation, resulting in a tight association between cAMP and contraction.

TL;DR: Beat-to-beat Vm fluctuations during late DD phase reflect the underlying LCR/INCX events, and the ensemble of these events forms the nonlinear DD component that ultimately controls the SANC chronotropic state in tight cooperation with surface membrane ion channels.