E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation.
Dongmei Yang,Christopher H. Morrell,Christopher H. Morrell,Alexey E. Lyashkov,Syevda Tagirova Sirenko,Ihor Zahanich,Yael Yaniv,Tatiana M. Vinogradova,Bruce D. Ziman,Victor A. Maltsev,Edward G. Lakatta +10 more
TL;DR: In this paper, the authors show that Ca2+ and V m domain kinetic transitions (time to AP ignition in diastole and 90% AP recovery) occurring within given AP, the mean APFIs, and APFI variabilities within the time series of APs in 230 individual nodal cells are self-similar (obey power laws).
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelos Evangelou,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsu,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrer,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Praveen Surendran,Sébastien Thériault,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Boomsma, Dorret, I,Erwin P. Bottinger,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola M. Del Greco,Cumhur Y Demirkale,Marcus Doerr,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Alan James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Lorna M. Lopez,Yingchang Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Rotter, Jerome, I,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Antti-Pekka Sarin,Reinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Voelker,Peter Vollenweider,Dragana Vuckovic,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,John Attia,Adam S. Butterworth,Daniell Chasman,David Conen,Francesco Cucca,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook-Kanamori,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Levy,Patricia B. Munroe,Christopher Newton-Cheh,Morris J. Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Ioanna Tzoulaki,Michael R. Barnes,Louise V. Wain,Paul Elliott,Mark J. Caulfield +279 more
TL;DR: In this paper, the authors report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry, identifying 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures.
Journal ArticleDOI
The Sustained Release of Galardin and Taxol from Gelatin Chondroitin Sulfate Coacervate Films
Phillip F. Heller,G. Mark Jenkins,Linda Cheng,Kam W. Leong,Wen Shao,Jeffrey A. Brinker,Earl J. Hope,Cynthia Nater,Edward G. Lakatta,Jeffrey P. Froehlich +9 more
TL;DR: There is no effective strategy for preventing restenosis in man and percutaneous transluminal balloon angioplasty remains the limiting factor in the use of this treatment for coronary artery disease.
Posted ContentDOI
Discovering patterns of pleiotropy in genome-wide association studies
J Zhana,Jv Setten,James P. Brody,Brenton R. Swenson,Anne M. Butler,Harry Campbell,Fabiola M Del Greco,Daniel S. Evans,Q Gibson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Kathleen F. Kerr,Bouwe P. Krijthe,Leo-Pekka Lyytikäinen,Craig Muller,Martina Müller-Nurasyid,Ilja M. Nolte,Sandosh Padmanabhan,Ritchie,Antonietta Robino,Albert V. Smith,Maristella Steri,Toshiko Tanaka,Alexander Teumer,Stella Trompet,S. Ulivi,Niek Verweij,Xiaoyan Yin,Davíð O. Arnar,Davíð O. Arnar,Folkert W. Asselbergs,Folkert W. Asselbergs,John Barnard,J. C. Bis,Stefan Blankenberg,Eric Boerwinkle,Yuki Bradford,Brendan M. Buckley,Mina K. Chung,Diane M. Crawford,Hoed,Josh C. Denny,Anna F. Dominiczak,G. Ehret,Mark Eijgelsheim,Patrick T. Ellinor,Stephan B. Felix,Lude Franke,T.B. Harris,Susan R. Heckbert,Hilma Holm,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gandin Ilaria,Annamaria Iorio,Mika Kähönen,Ivana Kolcic,Jan A. Kors,Edward G. Lakatta,L. J. Launer,Honghuang Lin,Haonan Lin,Yongmei Liu,R. J. F. Loos,Steven A. Lubitz,Peter W. Macfarlane,Jared W. Magnani,Irene Mateo Leach,Thomas Meitinger,B. D. Mitchell,Thomas Münzel,George J. Papanicolaou,Annette Peters,A. Pfeufer,PM Pramstaller,Olli T. Raitakari,Jerome I. Rotter,Igor Rudan,Nilesh J. Samani,David Schlessinger,CT Aldana Silva,Moritz F. Sinner,Jonathan D. Smith,Harold Snieder,Elsayed Z. Soliman,Tim D. Spector,David J. Stott,Konstantin Strauch,Kirill V. Tarasov,A.G. Uitterlinden,Wagoner van,Uwe Völker,Henry Völzke,M. Waldenberger,Harm-Jan Westra,Philipp S. Wild,Tanja Zeller,Alvaro Alonso,Christy L. Avery,Stefania Bandinelli,E J Benjamin,Francesco Cucca,Steven R. Cummings,Marcus Dörr,L Ferrucci,Paolo Gasparini,Vilmundar Gudnason,Caroline Hayward,Andrew A. Hicks,Yalda Jamshidi,Joop Jukema,Stefan Kääb,Terho Lehtimäki,Patricia B. Munroe,Afshin Parsa,O Polasekd,Bruce M. Psaty,Dan M. Roden,Renate B. Schnabel,Gianfranco Sinagra,Kari Stefansson,Kari Stefansson,Bruno H. Stricker,Pv Harst der,CM Duijn van,James F. Wilson,Sina A. Gharib,Pi Bakker de,A Isaacs,Dan E. Arking,N. Sotoodehnia,JS Baderab +131 more
TL;DR: Two methods based on a Bayesian framework, SNP And Pleiotropic PHenotype Organization (SAPPHO) and the other incorporating a full phenotype covariance structure are introduced, which learn patterns of pleiotropy from genotype and phenotype data, using identified associations to discover additional associations with shared patterns.
Journal ArticleDOI
Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells.
Alexander V. Maltsev,Sean P. Parsons,Mary S. Kim,Kenta Tsutsui,Michael D. Stern,Edward G. Lakatta,Victor A. Maltsev,Oliver Monfredi +7 more
TL;DR: In this paper, the authors measured local Ca2+ releases (LCRs) in spontaneously contracting sinoatrial (SA) node cells isolated from rabbit and guinea pig and developed a new algorithm capable of detecting and analyzing the LCRs spatially in two-dimensions, and in time.