E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Angiotensin II Activates Matrix Metalloproteinase Type II and Mimics Age-Associated Carotid Arterial Remodeling in Young Rats
Mingyi Wang,Jing Zhang,Gaia Spinetti,Liqun Jiang,Robert E. Monticone,Di Zhao,Linda Cheng,Melissa Krawczyk,Mark I. Talan,Gianfranco Pintus,Edward G. Lakatta +10 more
TL;DR: Ang II-induced effects on MMP2, transforming growth factor-beta1, collagen, and VSMCs are central to the arterial remodeling that accompanies advancing age.
Journal ArticleDOI
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
Wei-Min Chen,Michael R. Erdos,Anne U. Jackson,Richa Saxena,Serena Sanna,Serena Sanna,Kristi D. Silver,Nicholas J. Timpson,Torben Hansen,Marco Orrù,Maria Grazia Piras,Lori L. Bonnycastle,Cristen J. Willer,Valeriya Lyssenko,Haiqing Shen,Johanna Kuusisto,Shah Ebrahim,Natascia Sestu,William L. Duren,Maria Cristina Spada,Heather M. Stringham,Laura J. Scott,Nazario Olla,Amy J. Swift,Samer S. Najjar,Braxton D. Mitchell,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Gitte Andersen,Knut Borch-Johnsen,Torben Jørgensen,Jouko Saramies,Timo T. Valle,Timo T. Valle,Thomas A. Buchanan,Alan R. Shuldiner,Edward G. Lakatta,Richard N. Bergman,Manuela Uda,Jaakko Tuomilehto,Jaakko Tuomilehto,Oluf Pedersen,Oluf Pedersen,Antonio Cao,Leif Groop,Karen L. Mohlke,Markku Laakso,David Schlessinger,Francis S. Collins,David Altshuler,Gonçalo R. Abecasis,Michael Boehnke,Angelo Scuteri,Richard M. Watanabe +54 more
TL;DR: The results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation.
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Is digoxin really important in treatment of compensated heart failure?. A placebo-controlled crossover study in patients with sinus rhythm
TL;DR: The results indicate that long-term digoxin therapy has only a minor effect on cardiac performance that is without apparent clinical importance in a representative population of ambulatory patients treated with cardiac glycosides.
Journal ArticleDOI
Kappa and delta opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons.
TL;DR: The hypothesis that delta and kappa opioid receptor stimulation may cause sarcoplasmic reticulum Ca2+ depletion is tested and it is shown that this effect is coupled to phosphatidylinositol turnover and, at least in part, may be due to sarcoplasmsic retICulum Ca 2+ depletion.
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Role of inflammation in the pathogenesis of arterial stiffness.
Sungha Park,Edward G. Lakatta +1 more
TL;DR: There is rationale for targeting specific inflammatory pathways involved in arterial stiffness in the development of future drugs, including drugs that block the activation of the RAS system, among the major classes of anti hypertensive drugs.