E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.
Jessica van Setten,Jennifer A. Brody,Yalda Jamshidi,Brenton R. Swenson,Anne M. Butler,Harry Campbell,Fabiola M. Del Greco,Daniel S. Evans,Quince Gibson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Kathleen F. Kerr,Bouwe P. Krijthe,Leo-Pekka Lyytikäinen,Christian Müller,Martina Müller-Nurasyid,Ilja M. Nolte,Sandosh Padmanabhan,Marylyn D. Ritchie,Antonietta Robino,Albert V. Smith,Albert V. Smith,Maristella Steri,Toshiko Tanaka,Alexander Teumer,Stella Trompet,Sheila Ulivi,Niek Verweij,Xiaoyan Yin,David O. Arnar,David O. Arnar,Folkert W. Asselbergs,Folkert W. Asselbergs,Joel S. Bader,John Barnard,J. C. Bis,Stefan Blankenberg,Eric Boerwinkle,Yuki Bradford,Brendan M. Buckley,Mina K. Chung,Dana C. Crawford,Marcel den Hoed,Josh C. Denny,Anna F. Dominiczak,Georg Ehret,Mark Eijgelsheim,Mark Eijgelsheim,Patrick T. Ellinor,Patrick T. Ellinor,Stephan B. Felix,Oscar H. Franco,Lude Franke,Tamara B. Harris,Hilma Holm,Gandin Ilaria,Annamaria Iorio,Mika Kähönen,Ivana Kolcic,Jan A. Kors,Edward G. Lakatta,Lenore J. Launer,Honghuang Lin,Henry J. Lin,Ruth J. F. Loos,Steven A. Lubitz,Steven A. Lubitz,Peter W. Macfarlane,Jared W. Magnani,Irene Mateo Leach,Thomas Meitinger,Braxton D. Mitchell,Thomas Münzel,George J. Papanicolaou,Annette Peters,Arne Pfeufer,Peter P. Pramstaller,Olli T. Raitakari,Jerome I. Rotter,Igor Rudan,Nilesh J. Samani,David Schlessinger,Claudia T. Silva Aldana,Claudia T. Silva Aldana,Moritz F. Sinner,Jonathan D. Smith,Harold Snieder,Elsayed Z. Soliman,Tim D. Spector,David J. Stott,Konstantin Strauch,Kirill V. Tarasov,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,André G. Uitterlinden,David R. Van Wagoner,Uwe Völker,Henry Völzke,Melanie Waldenberger,Harm-Jan Westra,Philipp S. Wild,Tanja Zeller,Alvaro Alonso,Christy L. Avery,Stefania Bandinelli,Emelia J. Benjamin,Francesco Cucca,Marcus Dörr,Luigi Ferrucci,Paolo Gasparini,Vilmundur Gudnason,Caroline Hayward,Susan R. Heckbert,Andrew A. Hicks,J. Wouter Jukema,Stefan Kääb,Terho Lehtimäki,Yongmei Liu,Patricia B. Munroe,Afshin Parsa,Ozren Polasek,Ozren Polasek,Bruce M. Psaty,Bruce M. Psaty,Dan M. Roden,Renate B. Schnabel,Gianfranco Sinagra,Kari Stefansson,Kari Stefansson,Bruno H. Stricker,Pim van der Harst,Cornelia M. van Duijn,James F. Wilson,Sina A. Gharib,Paul I.W. de Bakker,Aaron Isaacs,Dan E. Arking,Nona Sotoodehnia +137 more
TL;DR: Findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.
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Age-associated changes in the components of atrioventricular conduction in apparently healthy volunteers.
TL;DR: The modest age-associated prolongation of the P-R interval is localized to the proximal P- R segment, probably reflecting delay within the atrioventricular junction, which is responsible for first degree A-V block in apparently healthy older men.
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Starling's law of the heart is explained by an intimate interaction of muscle length and myofilament calcium activation
TL;DR: "Contractile" or "inotropic" state as it refers to the extent of myofilament activation can, in theory, no longer be considered independent of the muscle length, as was formerly thought to be the case.
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Neuroticism, coronary artery disease, and chest pain complaints: Cross-sectional and longitudinal studies
TL;DR: In this paper, the authors analyzed chest pain reports and other CAD symptoms in the context of a model of personality and health which emphasizes the role of the enduring disposition of neuroticism as a determinant of perceptions of health.
Journal ArticleDOI
Dissociation of changes in apparent myofibrillar Ca2+ sensitivity and twitch relaxation induced by adrenergic and cholinergic stimulation in isolated ferret cardiac muscle.
TL;DR: The effects of ACh and ISN of modulating the apparent myofilament Ca2+ sensitivity in intact muscles, corroborate findings of previous studies in isolated myofibrillar preparations.