E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates.
Mereena George Ushakumary,Mingyi Wang,Harikrishnan,Allen Sam Titus,Jing Zhang,Lijuan Liu,Robert E. Monticone,Yushi Wang,Yushi Wang,Julie A. Mattison,Rafael de Cabo,Edward G. Lakatta,Shivakumar Kailasam +12 more
TL;DR: A significant increase in collagen type 1 levels along with collagen and ECM remodeling, degradation of elastic laminae, enhanced fat deposition and calcification in the abdominal aorta in a non-human primate model of high-fat, high-sucrose diet (HFS)-induced metabolic syndrome is reported.
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Role of Body Size on Cardiovascular Function. Can We See the Meat Through the Fat
TL;DR: 2 important issues facing CV research are highlighted: which body dimension descriptor, height, weight, body mass index (BMI), or body surface area (BSA), is optimal for scaling various CV measures; and which mathematical scaling method should be used.
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Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice.
Mark A. Hutchinson,Han Sol Park,Kimberly J. Zanotti,Juan Alvarez-Gonzalez,Jing Zhang,Li Zhang,Richard Telljohann,Mingyi Wang,Edward G. Lakatta,Patricia J. Gearhart,Robert W. Maul +10 more
TL;DR: In this paper, a hierarchical order of antibody specificity was found for plaque formation in ApoE-/- Aid-/- mice compared to C57BL/6J controls, suggesting a more complex dynamic than previously described.
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Linkage of Cardiac Gene Expression Profiles and ETS2 with Lifespan Variability in Rats
Anna Sheydina,Maria Volkova,Liqun Jiang,Ondrej Juhasz,Jing Zhang,Hyun Jin Tae,Maria Grazia Perino,Mingyi Wang,Yi Zhu,Edward G. Lakatta,Kenneth R. Boheler +10 more
TL;DR: Variations in ETS2 abundance in hearts of adult rodents and the associated loss of CMs contribute at least partially, to the longevity variability observed during normal aging of rats through activation of programmed necrosis.
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Physiologic gating properties of unitary cardiac L-type Ca2+ channels.
Ira R. Josephson,Ira R. Josephson,Antonio Guia,Eric A. Sobie,Eric A. Sobie,W. Jonathan Lederer,Edward G. Lakatta,Michael D. Stern +7 more
TL;DR: Novel results establish the voltage-dependence of unitary LCC gating kinetics using a physiologic Ca(2+) ion concentration and provide insight into localCa(2+)-induced Ca( 2+) release and a more accurate basis for mathematical modeling of excitation-contraction coupling in cardiac myocytes.