E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk : the AortaGen Consortium
Gary F. Mitchell,Germaine C. Verwoert,Kirill V. Tarasov,Aaron Isaacs,Albert V. Smith,Yasmin,Ernst Rietzschel,Toshiko Tanaka,Yongmei Liu,Afshin Parsa,Samer S. Najjar,Kevin M. O'Shaughnessy,Sigurdur Sigurdsson,Marc De Buyzere,Martin G. Larson,Martin G. Larson,Mark P.S. Sie,Jeanette S. Andrews,Wendy S. Post,Francesco U.S. Mattace-Raso,Carmel M. McEniery,Gudny Eiriksdottir,Patrick Segers,Ramachandran S. Vasan,Ramachandran S. Vasan,Marie Josee E. van Rijn,Timothy D. Howard,Patrick F. McArdle,Patrick F. McArdle,Abbas Dehghan,Elizabeth S. Jewell,Stephen Newhouse,Sofie Bekaert,Naomi M. Hamburg,Anne B. Newman,Albert Hofman,Angelo Scuteri,Dirk De Bacquer,Mohammad Arfan Ikram,Bruce M. Psaty,Christian Fuchsberger,Matthias Olden,Matthias Olden,Louise V. Wain,Paul Elliott,Nicholas L. Smith,Janine F. Felix,Jeanette Erdmann,Joseph A. Vita,Kim Sutton-Tyrrell,Eric J.G. Sijbrands,Serena Sanna,Lenore J. Launer,Tim De Meyer,Andrew D. Johnson,Anna F.C. Schut,David M. Herrington,Fernando Rivadeneira,Manuela Uda,Ian B. Wilkinson,Thor Aspelund,Thierry C. Gillebert,Luc M. Van Bortel,Emelia J. Benjamin,Emelia J. Benjamin,Emelia J. Benjamin,Ben A. Oostra,Jingzhong Ding,Quince Gibson,Quince Gibson,André G. Uitterlinden,Gonçalo R. Abecasis,John R. Cockcroft,Vilmundur Gudnason,Guy De Backer,Luigi Ferrucci,Tamara B. Harris,A. R. Shuldiner,A. R. Shuldiner,Cornelia M. van Duijn,Daniel Levy,Edward G. Lakatta,Jacqueline C.M. Witteman +82 more
TL;DR: Common genetic variation in a locus in the 3′-BCL11B gene desert that is thought to harbor 1 or more gene enhancers is associated with higher CFPWV and increased risk for cardiovascular disease.
Journal ArticleDOI
Extracellular ATP has a potent effect to enhance cystolic calcium and contractility in single ventricular myocytes
Robert S. Danziger,Stefano Raffaeli,Rafael Moreno-Sánchez,Makoto Sakai,Maurizio C. Capogrossi,Harold A. Spurgeon,Richard G. Hansford,Edward G. Lakatta +7 more
TL;DR: In rat cardiac myocytes ATP stimulates trans-sarcolemmal influx of Ca2+: ADP, AMP and adenosine are ineffective and ATP markedly augments the amplitude of the Cai transient elicited by electrical stimulation thus rendering it a potent inotropic agent.
Journal ArticleDOI
Modern concepts concerning the origin of the heartbeat.
TL;DR: A review of the present paradigm is presented, including a look back at important steps that led to where the authors are today, alongside a glimpse into the exciting future of pacemaker research.
Journal ArticleDOI
Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension.
Olga V. Fedorova,Simbirtsev Andrey S,Nikolai I. Kolodkin,Alexander Kotov,Natalia I. Agalakova,Natalia I. Agalakova,Vladimir A. Kashkin,Natalia I Tapilskaya,Anton Bzhelyansky,Vitaly A. Reznik,Elena V. Frolova,Elena R Nikitina,Georgy V Budny,Dan L. Longo,Edward G. Lakatta,Alexei Y. Bagrov +15 more
TL;DR: Anti-MBG mAbs may be a useful tool in studies of MBG in vitro and in vivo and may offer treatment of preeclampsia.
Journal ArticleDOI
Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study.
Angelo Scuteri,Marco Orru,Christopher H. Morrell,Maria Grazia Piras,Dennis D. Taub,David Schlessinger,Manuela Uda,Edward G. Lakatta +7 more
TL;DR: The co-occurrence of both MetS and higher cytokines levels was associated with greater increases in arterial stiffness and thickness, suggesting a possible synergistic effect ofmetabolic syndrome and inflammation on the arterial wall.