E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Cardiotonic Steroids Induce Vascular Fibrosis Via Pressure-Independent Mechanism in NaCl-Loaded Diabetic Rats.
Olga V. Fedorova,Artem V. Fadeev,Yulia Grigorova,Courtney A. Marshall,Valentina Zernetkina,Nikolai I. Kolodkin,Natalia I. Agalakova,Alexandra Konradi,Edward G. Lakatta,Alexei Y. Bagrov +9 more
TL;DR: The results suggest that in salt-loaded diabetic rats MBG stimulates aortic collagen synthesis in a pressure-independent fashion, and that two pro-fibrotic mechanisms, Fli1-dependent and TGFβ-dependent, underlie its effects.
Ca 2 -stimulated Basal Adenylyl Cyclase Activity Localization in Membrane Lipid Microdomains of Cardiac Sinoatrial Nodal
Antoine Younes,Alexey E. Lyashkov,David R. Graham,Anna Sheydina,Maria Volkova,Megan Mitsak,Tatiana M. Vinogradova,Yevgeniya O. Lukyanenko,Yue Li,Abdul M. Ruknudin,Kenneth R. Boheler,Jennifer E. Van Eyk,Edward G. Lakatta +12 more
TL;DR: Adrenergic receptor( -AR) inverse agonists to alter the spontaneous, basal SANC firing rate indicates that high levels of cAMP are not due to constitutive activity of -ARs, suggesting high constitutive level of AC activity.
Journal ArticleDOI
Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.
Matt T. Oberdier,Christopher H. Morrell,Christopher H. Morrell,Edward G. Lakatta,Luigi Ferrucci,Majd AlGhatrif,Majd AlGhatrif +6 more
TL;DR: A modest longitudinal decline in ABI beyond the age of 70 years was shown to be independent of traditional risk factors for peripheral arterial disease but was accounted for by an increase in pulse wave velocity.