E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Use of erythropoietin and derivatives for treating hypertension
TL;DR: In this paper, the authors found that rhEPO leads to a significant reduction in arterial blood pressure via nitric oxide signaling, and further disclosed that an EPO derivative, helix B surface peptide (HBSP), significantly reduces blood pressure, kidney damage and myocardial fibrosis in animal models of hypertension.
Journal ArticleDOI
Digitalis in Congestive Heart Failure
Jerome L. Fleg,Edward G. Lakatta +1 more
TL;DR: Excerpt To the editors: The authors read the interesting review by Mulrow and associates (1) and wish to clarify a few points, particularly with regard to their own study (2), although they did not explicitly refer to this review in their study.
Journal ArticleDOI
Autonomic innervation, a peripheral glial cell web, and a novel S100B expressing interstitial cell type impart structural and functional complexity to the sinoatrial node.
Rostislav Bychkov,Magdalena Juhaszova,Miguel Calvo-Rubio Barrera,L. A. Donald,Christopher E. Coletta,Chad Shumaker,Kayla Moorman,Syevda Tagirova,Alexander V. Maltsev,Steven J. Sollott,Edward G. Lakatta +10 more
TL;DR: In this paper , the authors described the sinoatrial node (SAN) as composed of a HCN4+-pacemaker cell meshwork, which merges with a network of connexin 43+/F-actin+ cells.
Posted ContentDOI
Emergence of Heartbeat Frailty in Advanced Age: Perspectives from Life-Long EKG Recordings in Mice
Jack M. Moen,Christopher H. Morrell,Ismayil Ahmet,Michael G. Matt,Moran Davoodi,Michael A. Petr,Shaquille J.C. Charles,R. deCabo,Yael Yaniv,Edward G. Lakatta +9 more
TL;DR: The progressive increase in intrinsic RR interval variability beyond 21 months of age is interpreted to be an indication of heartbeat frailty.
Journal Article
ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta. Commentary
Vardaman M. Buckalew,Olga V. Fedorova,Natalia I. Agalakova,Christopher H. Morrell,Edward G. Lakatta,Alexei Y. Bagrov +5 more
TL;DR: Assessment of effects of ANP on Na/K-ATPase phosphorylation and inhibition by an endogenous sodium pump ligand, marinobufagenin, in the aorta and renal medulla from male Sprague–Dawley rats suggests that α-1 Na/k-atPase inhibition by marinOBufagenIn in the kidney is enhanced via Na/ K- ATPaseosphorylation by ANP, whereas in theAorta