Edward G. Lakatta

TL;DR: Results demonstrate unequivocally that RyR activation by a single LCC is accelerated and synchronized during βAR stimulation, and this molecular mechanism of sympathetic regulation will permit more fundamental studies of altered βAR effects in cardiovascular diseases.

TL;DR: To determine whether this dose of amiloride inhibits the manifestations of sodium-mediated calcium gain in the same model during normoxia, the metabolic and functional sequelae of lithium-substituted low sodium (50 mM) perfusion were studied.

TL;DR: C-SNARF-1 can be calibrated in situ using a technique that abolishes all transsarcolemmal pH gradients and the contribution of cellular autofluorescence to the total signal can be made negligible.

TL;DR: The study has discovered a novel, microscopic Ca2+ signaling paradigm of SAN operation that has escaped detection using low-resolution, macroscopic tissue isochrones employed in prior studies: synchronized APs emerge from heterogeneous subcellular subthreshold Ca2- signals, resembling multiscale complex processes of impulse generation within clusters of neurons in neuronal networks.