E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
Papers
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Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprusside
Paul D. Chantler,Amit Nussbacher,Gary Gerstenblith,Steven P. Schulman,Lewis C. Becker,Luigi Ferrucci,Jerome L. Fleg,Edward G. Lakatta,Samer S. Najjar +8 more
TL;DR: It is hypothesized that sodium nitroprusside (SNP) can acutely ameliorate the age-associated deficits in E(A)/E(LV) and E(LV, in older subjects can be acutely abolished by SNP infusion.
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Design, generation, and testing of mammalian expression modules that tag membrane proteins
TL;DR: Two sets of expression modules are designed that consist of sequences encoding for three essential components: a signal peptide from human receptor for advanced glycation end products that targets the intended protein to the endoplasmic reticulum for cell surface expression, and an antigenic epitope tag that elicits specific antibody recognition.
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How useful is digitalis in patients with congestive heart failure and sinus rhythm
Jerome L. Fleg,Edward G. Lakatta +1 more
TL;DR: The current discussion will focus primarily on the evidence regarding the efficacy and risks of digitalis in patients with chronic CHF associated with sinus rhythm.
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Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease
Laura Monteonofrio,Maria Cristina Florio,Majd AlGhatrif,Majd AlGhatrif,Edward G. Lakatta,Maurizio C. Capogrossi,Maurizio C. Capogrossi +6 more
TL;DR: The effect of aging and gender on RAAS is addressed with emphasis on ACE2, pro- inflammatory Ang II/Ang II receptor 1 axis and anti-inflammatory Ang(1–7)/Mas receptor axis.
Journal Article
cGMP prevents delayed relaxation at reoxygenation after bried hypoxia in isolated cardiac myocytes
TL;DR: 8-BrcGMP fully prevents impaired posthypoxic relaxation in isolated cardiac myocytes, probably by altering Ca(2+)-myofilament interaction.