E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
Rui-Ping Xiao,Pavel V. Avdonin,Ying Ying Zhou,Heping Cheng,Shahab A. Akhter,Thomas Eschenhagen,Robert J. Lefkowitz,Walter J. Koch,Edward G. Lakatta +8 more
TL;DR: Beta2ARs in murine cardiac myocytes couple to concurrent Gs and Gi signaling, resulting in null inotropic response, unless the Gi signaling is inhibited, and results suggest that PTX-sensitive G proteins are responsible for the unresponsiveness of mouse heart to agonist-induced beta2AR stimulation.
Journal ArticleDOI
AGEMAP: a gene expression database for aging in mice.
Jacob M. Zahn,Suresh Poosala,Art B. Owen,Donald K. Ingram,Ana Lustig,Arnell Carter,Ashani T. Weeraratna,Dennis D. Taub,Myriam Gorospe,Krystyna Mazan-Mamczarz,Edward G. Lakatta,Kenneth R. Boheler,Xiangru Xu,Mark P. Mattson,Geppino Falco,Minoru S.H. Ko,David Schlessinger,Jeffrey Firman,Sarah K. Kummerfeld,William H. Wood,Alan B. Zonderman,Stuart K. Kim,Kevin G. Becker +22 more
TL;DR: The AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database is presented, which is a resource that catalogs changes in gene expression as a function of age in mice and finds great heterogeneity in the amount of transcriptional changes with age in different tissues.
Journal ArticleDOI
Common variants at ten loci modulate the QT interval duration in the QTSCD Study
Arne Pfeufer,Serena Sanna,Dan E. Arking,Martina Müller,Vesela Gateva,Christian Fuchsberger,Georg B. Ehret,Marco Orr,Cristian Pattaro,Anna Köttgen,Siegfried Perz,Gianluca Usala,Maja Barbalić,Man Li,Benno Pütz,Angelo Scuteri,Ronald J. Prineas,Moritz F. Sinner,Christian Gieger,Samer S. Najjar,W. H. Linda Kao,Thomas W. Mühleisen,Mariano Dei,Christine Happle,Stefan Möhlenkamp,Laura Crisponi,Raimund Erbel,K. H. Jöckel,Silvia Naitza,Gerhard Steinbeck,Fabio Marroni,Andrew A. Hicks,Edward G. Lakatta,Bertram Müller-Myhsok,Peter P. Pramstaller,H.-Erich Wichmann,David Schlessinger,Eric Boerwinkle,Thomas Meitinger,Manuela Uda,Josef Coresh,Stefan Kääb,Gonçalo R. Abecasis,Aravinda Chakravarti +43 more
TL;DR: In this article, the authors analyzed genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P < 5 x 10(-8).
Journal ArticleDOI
Aortic Stiffness Is Associated With Visceral Adiposity in Older Adults Enrolled in the Study of Health, Aging, and Body Composition
Kim Sutton-Tyrrell,Anne B. Newman,Eleanor M. Simonsick,Richard J. Havlik,Marco Pahor,Edward G. Lakatta,Harold A. Spurgeon,Peter V. Vaitkevicius +7 more
TL;DR: Among older adults, higher levels of visceral fat are associated with greater aortic stiffness as measured by pulse wave velocity, and this association was consistent across tertiles of body weight.
Journal Article
Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.
TL;DR: It is shown that pertussis toxin (PTX) pretreatment specifically potentiates the responses of rat heart cells to beta 2AR but not beta 1AR stimulation, and that the Gs-coupled beta 2 AR can simultaneously activate a pathway that leads to functional inhibition in cardiac cells via a PTX-sensitive G protein.