Edward G. Lakatta

TL;DR: In this article, the authors identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals, and 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues.

TL;DR: It is concluded that the intrinsic inotropic response to catecholamines is diminished in the aged myocardium and this finding does not appear to result from differences in tachyphylaxis, tissue uptake of catechlamines, or the ability of the contractile proteins to respond to increasing concentrations of calcium but instead may result from a decreased ability of ctcholamines to increase the intracellular calcium available for contraction.

TL;DR: Increased numbers of apoptotic cells are present in failing SHR hearts, suggesting that apoptosis might be a mechanism involved in the reduction of myocyte mass that accompanies the transition from stable compensation to heart failure in this model.

TL;DR: Results suggest that VSMC migration in vivo may be dependent on MMP2 activity, which could be regulated by the phenotypic state of VSMCs and increase as these cells undergo the transition from a quiescent and differentiated state to that of a dedifferentiated, proliferating, and motile phenotype after injury to the vessel.

TL;DR: The results suggest that the intracellular signaling pathways activated by p53 might play a critical role in the regulation of hypoxia-induced apoptosis of cardiomyocytes.