E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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Journal ArticleDOI
Age-associated decrease in ventricular response to haemodynamic stress during beta-adrenergic blockade.
Frank C.P. Yin,Frank C.P. Yin,Gary S. Raizes,Gary S. Raizes,Thomas Guarnieri,Thomas Guarnieri,Harold A. Spurgeon,Harold A. Spurgeon,Edward G. Lakatta,Nicholas J. Fortuin,Nicholas J. Fortuin,Myron L. Weisfeldt +11 more
TL;DR: Echocardiography could be used as an invasive method of determining the effects ofaging on theability of the left ventricle to respond to haemodynamic stress to detect age changes in left ventricular function anddimensions.
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Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals
Yael Yaniv,Yael Yaniv,Ismayil Ahmet,Jie Liu,Jie Liu,Alexey E. Lyashkov,Toni Rose Guiriba,Yosuke Okamoto,Bruce D. Ziman,Edward G. Lakatta +9 more
TL;DR: Both the average beating interval in vivo and beating interval complexity are conferred by the combined effects of clock periodicity intrinsic to pacemaker cells and their response to autonomic neural input.
Journal ArticleDOI
The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.
Edward G. Lakatta,Tatiana M. Vinogradova,Alexey E. Lyashkov,Syevda Sirenko,Weizong Zhu,Abdul M. Ruknudin,Victor A. Maltsev +6 more
TL;DR: In this article, the authors show that the Sinoatrial nodal cell (SANC) action potential (AP) is entrained and stabilized by the tight integration of the SR Ca 2+ Clock that generates rhythmic SCaRIE, and the surface membrane Clock that responds to SC aRIE to immediately produce APs of an adequate shape.
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ATPase activity and force production in myofibrils and twitch characteristics in intact muscle from neonatal, adult, and senescent rat myocardium.
TL;DR: It is concluded that the twitch prolongation of the senescent myocardium cannot be directly related to the age-related decline in myofibrillar ATPase activity.
Journal ArticleDOI
Hemodynamic effects of unloading the old heart.
Amit Nussbacher,Gary Gerstenblith,Frances C. O'Connor,Lewis C. Becker,David A. Kass,Steven P. Schulman,Jerome L. Fleg,Edward G. Lakatta +7 more
TL;DR: Combined preload and afterload reduction with NP in older individuals improves overall LV ejection phase function: exercise LV stroke work is reduced, EF is increased, and stroke volume is maintained in the setting of a reduced ventricular size.