E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
Papers
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Journal ArticleDOI
Coupled-Clock Pacemaker System becomes Dysfunctional with Aging
Syevda Sirenko,Magdalena Juhaszova,Jie Liu,Ismayil Ahmet,Steven J. Sollott,Edward G. Lakatta +5 more
TL;DR: A deterioration in intrinsic Ca2+-clock kinetics in aged SANC due to deficits in intrinsic SR Ca2-cycling and its response to a PDE stress appears to be involved in age-associated reduction in intrinsic resting AP-firing rate, and intrinsic HR in vivo.
Journal ArticleDOI
CaMKII-Dependent Phosphorylation Modulates Ca2+ Cycling in Sinoatrial Node Cells to Regulate Cardiac Pacemaker Function
Tatiana M. Vinogradova,Syevda Sirenko,Yue Li,Dongmei Yang,Harold A. Spurgeon,Edward G. Lakatta +5 more
TL;DR: Normal automaticity of rabbit sinoatrial node cells (SANC) is regulated by basal CaMKII-dependent phosphorylation, partly via modulation of intrinsic SR Ca2+ cycling, i.e. SR Ca 2+ pumping and release attained throughosphorylation of PLB and RyR.
Posted ContentDOI
Discoidin Domain Receptor 2 regulates AT1 receptor expression in Angiotensin II-stimulated cardiac fibroblasts via fibronectin-dependent Integrin-β1 signalling
Allen Sam Titus,Harikrishnan Venugopal,Mereena George Ushakumary,Mingyi Wang,Randy T. Cowling,Edward G. Lakatta,Shivakumar Kailasam +6 more
TL;DR: In this article, the authors investigated the role of fibronectin gene expression in cardiac fibroblasts exposed to Angiotensin II, a major pro-fibrotic factor in the myocardium.
Patent
Nucleic acid modules for expression and tagging of membrane proteins and methods of use
TL;DR: In this paper, the nucleic acid modules can be used to express any type of membrane protein and are particularly suited to the expression and tagging of Type I and Type III membrane proteins.
Journal ArticleDOI
Spontaneous Beating of Rabbit Sinoatrial Node Cells Requires Basal Protein Kinase C Activity
TL;DR: The data show for the first time that the basal PKC-dependent activity regulates spontaneous SANC beating rate through modulation of LCRs from RyR, while IP3 receptors make no substantial contribution in this effect.