E
Edward G. Lakatta
Researcher at National Institutes of Health
Publications - 902
Citations - 95504
Edward G. Lakatta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 146, co-authored 858 publications receiving 88637 citations. Previous affiliations of Edward G. Lakatta include University of Pittsburgh & University College London.
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A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8
Kirill V. Tarasov,Khalid Chakir,Daniel R. Riordon,Alexey E. Lyashkov,Ismayil Ahmet,Maria Grazia Perino,Allwin Jennifa Silvester,Jing Zhang,Mingyi Wang,Yevgeniya O. Lukyanenko,Jiau-hua Qu,Miguel Calvo-Rubio Barrera,Magdalena Juhaszova,Yelena S. Tarasova,Bruce D. Ziman,Richard Telljohann,Vikas Kumar,Mark J. Ranek,J. M. Lammons,Rostislav Bychkov,Rafael de Cabo,Seungho Jun,Gizem Keceli,Ashish Gupta,Dongmei Yang,Miguel A. Aon,Luigi Adamo,Christopher H. Morrell,Walter Otu,Cameron T. Carroll,Shane Alexander Chambers,Nazareno Paolocci,Thanh-Truc Huynh,Karel Pacak,Robert G. Weiss,Loren J. Field,Steven J. Sollott,Edward G. Lakatta +37 more
TL;DR: In this article , the authors show that cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TGAC8) adapts to an increased cAMP-induced cardiac workload for up to a year without signs of heart failure or excessive mortality.
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A monoclonal antibody to an endogenous Na/K-ATPase ligand, marinobufagenin, reverses expression of pro-fibrotic genes and reduces cardiovascular fibrosis in aged rats
Olga V. Fedorova,Victoria Shilova,Valentina Zernetkina,Yonqing Zhang,Elin Lehrmann,Kevin G. Becker,Edward G. Lakatta,Alexei Y. Bagrov +7 more
exerciseperformance at rest and during Arterial-ventricular coupling: mechanistic insights into
Paul D. Chantler,Edward G. Lakatta,Samer S. Najjar,Mahesh Nirmalan,Paul Dark,Sonnet S. Jonker,George D. Giraud,Herbert M. Espinoza,Erica N. Davis,A Dane +9 more
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Age-dependent hypertension and vascular remodeling in dahl-s rats are associated with elevated levels of marinobufagenin and cognitive decline
Olga V. Fedorova,Yulia Grigorova,M. Hagood,R. Mcdevitt,J. Long,R. Mcpherson,A. Naraine,Ondrej Juhasz,Wen Wei,V. Zernetkina,N. Petrashevskaya,Kenneth W. Fishbein,Richard G. Spencer,P.R. Rapp,Edward G. Lakatta +14 more
TL;DR: Cognitive deficit in aged hypertensive Dahl-S is limited to hippocampal-dependent spatial memory, and development of age-dependent hypertension and aortic wall remodeling, occurred in context with an increase in MBG, and suggested a possible implication of MBG in these declines.
Journal ArticleDOI
What makes the sinoatrial node tick? A question not for the faint of heart
L. A. Donald,Edward G. Lakatta +1 more
TL;DR: In this paper , the authors discuss recent discoveries that contextualize the coupled-clock system, first described in isolated sinoatrial node cells, into the complex world of SAN tissue: heterogeneous local Ca2+ releases, generated within SAN pacemaker cells and regulated by the other cell types within the SAN cytoarchitecture, variably co-localize and synchronize to give rise to relatively rhythmic impulses that emanate from the SAN to excite the heart.